node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMPD2 | ATIC | ENSCAFP00000031117 | ENSCAFP00000021114 | Adenosine monophosphate deaminase 2. | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 0.917 |
AMPD2 | GMPR | ENSCAFP00000031117 | ENSCAFP00000014617 | Adenosine monophosphate deaminase 2. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.937 |
AMPD2 | HPRT1 | ENSCAFP00000031117 | ENSCAFP00000037274 | Adenosine monophosphate deaminase 2. | Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). | 0.938 |
AMPD2 | IMPDH1 | ENSCAFP00000031117 | ENSCAFP00000002420 | Adenosine monophosphate deaminase 2. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.953 |
AMPD2 | NT5C | ENSCAFP00000031117 | ENSCAFP00000035634 | Adenosine monophosphate deaminase 2. | 5', 3'-nucleotidase, cytosolic. | 0.966 |
AMPD2 | NT5C1A | ENSCAFP00000031117 | ENSCAFP00000004570 | Adenosine monophosphate deaminase 2. | 5'-nucleotidase, cytosolic IA. | 0.939 |
AMPD2 | NT5E | ENSCAFP00000031117 | ENSCAFP00000004456 | Adenosine monophosphate deaminase 2. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.962 |
AMPD2 | NT5M | ENSCAFP00000031117 | ENSCAFP00000041751 | Adenosine monophosphate deaminase 2. | 5',3'-nucleotidase, mitochondrial. | 0.944 |
ATIC | AMPD2 | ENSCAFP00000021114 | ENSCAFP00000031117 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Adenosine monophosphate deaminase 2. | 0.917 |
ATIC | GMPR | ENSCAFP00000021114 | ENSCAFP00000014617 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.964 |
ATIC | GMPS | ENSCAFP00000021114 | ENSCAFP00000036506 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Uncharacterized protein. | 0.665 |
ATIC | HPRT1 | ENSCAFP00000021114 | ENSCAFP00000037274 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). | 0.925 |
ATIC | IMPDH1 | ENSCAFP00000021114 | ENSCAFP00000002420 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.964 |
ATIC | NT5C | ENSCAFP00000021114 | ENSCAFP00000035634 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 5', 3'-nucleotidase, cytosolic. | 0.905 |
ATIC | NT5C1A | ENSCAFP00000021114 | ENSCAFP00000004570 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 5'-nucleotidase, cytosolic IA. | 0.924 |
ATIC | NT5E | ENSCAFP00000021114 | ENSCAFP00000004456 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.927 |
ATIC | NT5M | ENSCAFP00000021114 | ENSCAFP00000041751 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 5',3'-nucleotidase, mitochondrial. | 0.904 |
GMPR | AMPD2 | ENSCAFP00000014617 | ENSCAFP00000031117 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Adenosine monophosphate deaminase 2. | 0.937 |
GMPR | ATIC | ENSCAFP00000014617 | ENSCAFP00000021114 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 0.964 |
GMPR | GMPS | ENSCAFP00000014617 | ENSCAFP00000036506 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Uncharacterized protein. | 0.990 |