| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCND1 | CCND2 | ENSCAFP00000061968 | ENSCAFP00000022654 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin D2; Belongs to the cyclin family. | 0.942 |
| CCND1 | CCND3 | ENSCAFP00000061968 | ENSCAFP00000061743 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin D3; Belongs to the cyclin family. | 0.950 |
| CCND1 | CDK4 | ENSCAFP00000061968 | ENSCAFP00000000402 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | 0.993 |
| CCND1 | CDK6 | ENSCAFP00000061968 | ENSCAFP00000002945 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. | 0.998 |
| CCND1 | CDKN2A | ENSCAFP00000061968 | ENSCAFP00000002445 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin dependent kinase inhibitor 2B. | 0.982 |
| CCND1 | ENSCAFP00000061562 | ENSCAFP00000061968 | ENSCAFP00000061562 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.967 |
| CCND1 | KRAS | ENSCAFP00000061968 | ENSCAFP00000064230 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | KRAS proto-oncogene, GTPase. | 0.578 |
| CCND1 | MDM2 | ENSCAFP00000061968 | ENSCAFP00000065951 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] | 0.670 |
| CCND1 | TP53 | ENSCAFP00000061968 | ENSCAFP00000064590 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.951 |
| CCND2 | CCND1 | ENSCAFP00000022654 | ENSCAFP00000061968 | Cyclin D2; Belongs to the cyclin family. | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | 0.942 |
| CCND2 | CCND3 | ENSCAFP00000022654 | ENSCAFP00000061743 | Cyclin D2; Belongs to the cyclin family. | Cyclin D3; Belongs to the cyclin family. | 0.929 |
| CCND2 | CDK4 | ENSCAFP00000022654 | ENSCAFP00000000402 | Cyclin D2; Belongs to the cyclin family. | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | 0.995 |
| CCND2 | CDK6 | ENSCAFP00000022654 | ENSCAFP00000002945 | Cyclin D2; Belongs to the cyclin family. | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. | 0.999 |
| CCND2 | CDKN2A | ENSCAFP00000022654 | ENSCAFP00000002445 | Cyclin D2; Belongs to the cyclin family. | Cyclin dependent kinase inhibitor 2B. | 0.955 |
| CCND2 | ENSCAFP00000061562 | ENSCAFP00000022654 | ENSCAFP00000061562 | Cyclin D2; Belongs to the cyclin family. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.936 |
| CCND2 | TP53 | ENSCAFP00000022654 | ENSCAFP00000064590 | Cyclin D2; Belongs to the cyclin family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.652 |
| CCND3 | CCND1 | ENSCAFP00000061743 | ENSCAFP00000061968 | Cyclin D3; Belongs to the cyclin family. | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | 0.950 |
| CCND3 | CCND2 | ENSCAFP00000061743 | ENSCAFP00000022654 | Cyclin D3; Belongs to the cyclin family. | Cyclin D2; Belongs to the cyclin family. | 0.929 |
| CCND3 | CDK4 | ENSCAFP00000061743 | ENSCAFP00000000402 | Cyclin D3; Belongs to the cyclin family. | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | 0.997 |
| CCND3 | CDK6 | ENSCAFP00000061743 | ENSCAFP00000002945 | Cyclin D3; Belongs to the cyclin family. | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. | 0.999 |
