STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1790 aa)    
Predicted Functional Partners:
SCG5
Secretogranin V.
   
 
 0.795
LPL
Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
     
 0.767
EXOC3L1
Exocyst complex component 3 like 1.
      
 0.696
MBTPS1
Membrane bound transcription factor peptidase, site 1.
      
 0.681
FKBP1B
Peptidylprolyl isomerase.
   
 
 0.642
SLC44A4
Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family.
   
  
 0.596
PDZD7
PDZ domain containing 7.
      
 0.591
BSND
Barttin CLCNK type accessory beta subunit.
      
 0.589
GDF11
Growth differentiation factor 11.
    
 
 0.573
CMYA5
Cardiomyopathy associated 5.
    
 
 0.528
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.