UBR2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

UBR2

E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)

Predicted Functional Partners:

TRIP12

0.960

UBR4

0.817

MYSM1

0.721

UBE2B

0.699

UBE2A

0.699

ENSCAFP00000056145

0.699

UBR5

0.695

MARCHF6

0.689

USP34

0.649

ZRANB1

0.643

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCAFP00000056145	TRIP12	ENSCAFP00000056145	ENSCAFP00000057207	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Thyroid hormone receptor interactor 12.	0.619
ENSCAFP00000056145	UBE2A	ENSCAFP00000056145	ENSCAFP00000027185	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family.	0.903
ENSCAFP00000056145	UBE2B	ENSCAFP00000056145	ENSCAFP00000001440	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family.	0.903
ENSCAFP00000056145	UBR2	ENSCAFP00000056145	ENSCAFP00000002487	UBIQUITIN_CONJUGAT_2 domain-containing protein.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.699
ENSCAFP00000056145	UBR4	ENSCAFP00000056145	ENSCAFP00000022600	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin protein ligase E3 component n-recognin 4.	0.628
MARCHF6	UBR2	ENSCAFP00000014784	ENSCAFP00000002487	Membrane associated ring-CH-type finger 6.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.689
MYSM1	TRIP12	ENSCAFP00000027892	ENSCAFP00000057207	Myb like, SWIRM and MPN domains 1.	Thyroid hormone receptor interactor 12.	0.561
MYSM1	UBR2	ENSCAFP00000027892	ENSCAFP00000002487	Myb like, SWIRM and MPN domains 1.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.721
MYSM1	USP34	ENSCAFP00000027892	ENSCAFP00000004484	Myb like, SWIRM and MPN domains 1.	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family.	0.474
MYSM1	ZRANB1	ENSCAFP00000027892	ENSCAFP00000059020	Myb like, SWIRM and MPN domains 1.	Zinc finger RANBP2-type containing 1.	0.581
TRIP12	ENSCAFP00000056145	ENSCAFP00000057207	ENSCAFP00000056145	Thyroid hormone receptor interactor 12.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.619
TRIP12	MYSM1	ENSCAFP00000057207	ENSCAFP00000027892	Thyroid hormone receptor interactor 12.	Myb like, SWIRM and MPN domains 1.	0.561
TRIP12	UBE2A	ENSCAFP00000057207	ENSCAFP00000027185	Thyroid hormone receptor interactor 12.	Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family.	0.619
TRIP12	UBE2B	ENSCAFP00000057207	ENSCAFP00000001440	Thyroid hormone receptor interactor 12.	Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family.	0.619
TRIP12	UBR2	ENSCAFP00000057207	ENSCAFP00000002487	Thyroid hormone receptor interactor 12.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.960
TRIP12	UBR4	ENSCAFP00000057207	ENSCAFP00000022600	Thyroid hormone receptor interactor 12.	Ubiquitin protein ligase E3 component n-recognin 4.	0.544
TRIP12	UBR5	ENSCAFP00000057207	ENSCAFP00000000890	Thyroid hormone receptor interactor 12.	Ubiquitin protein ligase E3 component n-recognin 5.	0.907
TRIP12	USP34	ENSCAFP00000057207	ENSCAFP00000004484	Thyroid hormone receptor interactor 12.	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family.	0.925
TRIP12	ZRANB1	ENSCAFP00000057207	ENSCAFP00000059020	Thyroid hormone receptor interactor 12.	Zinc finger RANBP2-type containing 1.	0.613
UBE2A	ENSCAFP00000056145	ENSCAFP00000027185	ENSCAFP00000056145	Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.903

page 1 of 3

Server load: low (36%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About