PAX4 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

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gene neighborhood

gene co-occurrence

gene fusions

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[Homology]

Score

PAX4

Paired box 4. (344 aa)

Predicted Functional Partners:

RFX6

0.834

INS

0.758

SST

0.756

PCSK1

0.740

SP3

0.733

FOXA2

0.721

FOXA1

0.716

ISL1

0.716

NEUROG3

0.712

SLC30A8

0.691

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FOXA1	FOXA2	ENSCAFP00000020254	ENSCAFP00000007716	Forkhead box A1.	Forkhead box A2.	0.443
FOXA1	PAX4	ENSCAFP00000020254	ENSCAFP00000002500	Forkhead box A1.	Paired box 4.	0.716
FOXA2	FOXA1	ENSCAFP00000007716	ENSCAFP00000020254	Forkhead box A2.	Forkhead box A1.	0.443
FOXA2	INS	ENSCAFP00000007716	ENSCAFP00000051648	Forkhead box A2.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.623
FOXA2	ISL1	ENSCAFP00000007716	ENSCAFP00000027248	Forkhead box A2.	ISL LIM homeobox 1.	0.624
FOXA2	PAX4	ENSCAFP00000007716	ENSCAFP00000002500	Forkhead box A2.	Paired box 4.	0.721
FOXA2	RFX6	ENSCAFP00000007716	ENSCAFP00000001307	Forkhead box A2.	Regulatory factor X6.	0.519
INS	FOXA2	ENSCAFP00000051648	ENSCAFP00000007716	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Forkhead box A2.	0.623
INS	ISL1	ENSCAFP00000051648	ENSCAFP00000027248	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	ISL LIM homeobox 1.	0.449
INS	NEUROG3	ENSCAFP00000051648	ENSCAFP00000031746	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Neurogenin 3.	0.610
INS	PAX4	ENSCAFP00000051648	ENSCAFP00000002500	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Paired box 4.	0.758
INS	PCSK1	ENSCAFP00000051648	ENSCAFP00000011663	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.670
INS	RFX6	ENSCAFP00000051648	ENSCAFP00000001307	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Regulatory factor X6.	0.463
INS	SLC30A8	ENSCAFP00000051648	ENSCAFP00000001179	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Solute carrier family 30 member 8.	0.546
INS	SST	ENSCAFP00000051648	ENSCAFP00000064277	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin.	0.924
ISL1	FOXA2	ENSCAFP00000027248	ENSCAFP00000007716	ISL LIM homeobox 1.	Forkhead box A2.	0.624
ISL1	INS	ENSCAFP00000027248	ENSCAFP00000051648	ISL LIM homeobox 1.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.449
ISL1	PAX4	ENSCAFP00000027248	ENSCAFP00000002500	ISL LIM homeobox 1.	Paired box 4.	0.716
ISL1	SST	ENSCAFP00000027248	ENSCAFP00000064277	ISL LIM homeobox 1.	Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin.	0.430
NEUROG3	INS	ENSCAFP00000031746	ENSCAFP00000051648	Neurogenin 3.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.610