Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
C11H9orf72Chromosome 11 C9orf72 homolog. (481 aa)    
Predicted Functional Partners:
SMCR8
SMCR8-C9orf72 complex subunit.
    
 0.998
WDR41
WD repeat domain 41.
    
 0.993
ATG13
Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.
  
 
 0.988
ULK1
Unc-51 like autophagy activating kinase 1.
    
 0.987
ALKAL1
RB1 inducible coiled-coil 1.
    
 0.983
ATG101
Autophagy related 101.
    
 0.971
ULK2
Unc-51 like autophagy activating kinase 2.
    
 0.962
RAB8A
Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...]
    
 0.865
RAB8B
RAB8B, member RAS oncogene family.
    
 0.865
EIF2B2
Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family.
    
  0.853
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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