CNPY3 protein (Canis lupus familiaris) - STRING interaction network

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Score

CNPY3

Canopy FGF signaling regulator 3. (279 aa)

Predicted Functional Partners:

HSP90B1

0.920

LRRC40

0.892

CNPY2

0.787

UNC93B1

0.713

TLR7

0.620

SFXN5

0.608

TLR9-2

0.605

TRPA1

0.597

OGN

0.594

TLR3

0.577

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNPY2	CNPY3	ENSCAFP00000000169	ENSCAFP00000002525	Saposin B-type domain-containing protein.	Canopy FGF signaling regulator 3.	0.787
CNPY2	HSP90B1	ENSCAFP00000000169	ENSCAFP00000057899	Saposin B-type domain-containing protein.	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	0.889
CNPY3	CNPY2	ENSCAFP00000002525	ENSCAFP00000000169	Canopy FGF signaling regulator 3.	Saposin B-type domain-containing protein.	0.787
CNPY3	HSP90B1	ENSCAFP00000002525	ENSCAFP00000057899	Canopy FGF signaling regulator 3.	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	0.920
CNPY3	LRRC40	ENSCAFP00000002525	ENSCAFP00000030292	Canopy FGF signaling regulator 3.	Leucine rich repeat containing 40.	0.892
CNPY3	OGN	ENSCAFP00000002525	ENSCAFP00000003355	Canopy FGF signaling regulator 3.	Osteoglycin.	0.594
CNPY3	SFXN5	ENSCAFP00000002525	ENSCAFP00000013151	Canopy FGF signaling regulator 3.	Sidoreflexin.	0.608
CNPY3	TLR3	ENSCAFP00000002525	ENSCAFP00000044568	Canopy FGF signaling regulator 3.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.577
CNPY3	TLR7	ENSCAFP00000002525	ENSCAFP00000043898	Canopy FGF signaling regulator 3.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.620
CNPY3	TLR9-2	ENSCAFP00000002525	ENSCAFP00000030804	Canopy FGF signaling regulator 3.	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	0.605
CNPY3	TRPA1	ENSCAFP00000002525	ENSCAFP00000011746	Canopy FGF signaling regulator 3.	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.597
CNPY3	UNC93B1	ENSCAFP00000002525	ENSCAFP00000045931	Canopy FGF signaling regulator 3.	Unc-93 homolog B1, TLR signaling regulator.	0.713
HSP90B1	CNPY2	ENSCAFP00000057899	ENSCAFP00000000169	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	Saposin B-type domain-containing protein.	0.889
HSP90B1	CNPY3	ENSCAFP00000057899	ENSCAFP00000002525	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	Canopy FGF signaling regulator 3.	0.920
HSP90B1	TLR3	ENSCAFP00000057899	ENSCAFP00000044568	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.645
HSP90B1	TLR7	ENSCAFP00000057899	ENSCAFP00000043898	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.637
HSP90B1	TLR9-2	ENSCAFP00000057899	ENSCAFP00000030804	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	0.655
HSP90B1	UNC93B1	ENSCAFP00000057899	ENSCAFP00000045931	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	Unc-93 homolog B1, TLR signaling regulator.	0.572
LRRC40	CNPY3	ENSCAFP00000030292	ENSCAFP00000002525	Leucine rich repeat containing 40.	Canopy FGF signaling regulator 3.	0.892
OGN	CNPY3	ENSCAFP00000003355	ENSCAFP00000002525	Osteoglycin.	Canopy FGF signaling regulator 3.	0.594