STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PHOX2BPaired like homeobox 2B. (314 aa)    
Predicted Functional Partners:
TH
Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons.
   
  
 0.919
MYO1H
Myosin IH; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
      
 0.786
DBH
Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline.
   
  
 0.777
HAND2
Heart and neural crest derivatives expressed 2.
   
 
 0.739
SOX10
SRY-box transcription factor 10.
      
 0.671
ASCL1
Achaete-scute family bHLH transcription factor 1.
   
 
 0.653
INSM2
INSM transcriptional repressor 2.
   
  
 0.644
SLC18A3
Solute carrier family 18 member A3.
   
  
 0.614
GATA3
GATA binding protein 3.
      
 0.611
EDN3
Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides.
   
  
 0.593
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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