STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PHOX2BPaired like homeobox 2B. (314 aa)    
Predicted Functional Partners:
TH
Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons.
   
  
 0.890
DBH
Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline.
   
 
 0.850
PHOX2A
Paired like homeobox 2A.
  
 
0.849
HAND2
Heart and neural crest derivatives expressed 2.
   
 
 0.821
PRDM12
PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily.
      
 0.818
MYO1H
Myosin IH; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
      
 0.794
SOX10
SRY-box transcription factor 10.
      
 0.719
INSM2
INSM transcriptional repressor 2.
   
  
 0.710
ASCL1
Achaete-scute family bHLH transcription factor 1.
   
 
 0.685
ATOH1
Atonal bHLH transcription factor 1.
      
 0.664
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.