STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CEMIP2Cell migration inducing hyaluronidase 2. (1383 aa)    
Predicted Functional Partners:
HABP4
Hyaluronan binding protein 4.
      
 0.673
AP2A2
AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]
   
  
 0.653
ITIH1
Inter-alpha-trypsin inhibitor heavy chain 1.
   
 
 0.583
ITIH3
Inter-alpha-trypsin inhibitor heavy chain 3.
   
 
 0.577
ITIH2
Inter-alpha-trypsin inhibitor heavy chain 2.
   
 
 0.571
SHROOM4
Shroom family member 4.
    
 
 0.571
SMPD3
Sphingomyelin phosphodiesterase 3.
   
  
 0.562
HAS3
Hyaluronan synthase 3.
      
 0.551
HAS1
Hyaluronan synthase 1.
   
  
 0.517
STAB2
Stabilin 2.
      
 0.483
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (40%) [HD]