SRF protein (Canis lupus familiaris) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

SRF

Serum response factor. (508 aa)

Predicted Functional Partners:

MYOCD

0.976

MRTFA

0.972

ELK1

0.954

NFATC4

0.926

NFATC3

0.918

GATA4

0.916

NFATC2

0.909

NFATC1

0.908

MRTFB

0.863

ETS1

0.854

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ELK1	SRF	ENSCAFP00000022360	ENSCAFP00000002675	ETS transcription factor ELK1.	Serum response factor.	0.954
ETS1	SRF	ENSCAFP00000044379	ENSCAFP00000002675	ETS proto-oncogene 1, transcription factor.	Serum response factor.	0.854
GATA4	MYOCD	ENSCAFP00000038219	ENSCAFP00000026366	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	Myocardin.	0.611
GATA4	NFATC1	ENSCAFP00000038219	ENSCAFP00000031585	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	Nuclear factor of activated T cells 1.	0.919
GATA4	NFATC2	ENSCAFP00000038219	ENSCAFP00000017095	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	Nuclear factor of activated T cells 2.	0.919
GATA4	NFATC3	ENSCAFP00000038219	ENSCAFP00000052790	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	Nuclear factor of activated T cells 3.	0.920
GATA4	NFATC4	ENSCAFP00000038219	ENSCAFP00000039115	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	Nuclear factor of activated T cells 4.	0.942
GATA4	SRF	ENSCAFP00000038219	ENSCAFP00000002675	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	Serum response factor.	0.916
MRTFA	SRF	ENSCAFP00000059792	ENSCAFP00000002675	Myocardin related transcription factor A.	Serum response factor.	0.972
MRTFB	SRF	ENSCAFP00000063528	ENSCAFP00000002675	Myocardin related transcription factor B.	Serum response factor.	0.863
MYOCD	GATA4	ENSCAFP00000026366	ENSCAFP00000038219	Myocardin.	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	0.611
MYOCD	SRF	ENSCAFP00000026366	ENSCAFP00000002675	Myocardin.	Serum response factor.	0.976
NFATC1	GATA4	ENSCAFP00000031585	ENSCAFP00000038219	Nuclear factor of activated T cells 1.	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	0.919
NFATC1	NFATC2	ENSCAFP00000031585	ENSCAFP00000017095	Nuclear factor of activated T cells 1.	Nuclear factor of activated T cells 2.	0.937
NFATC1	NFATC3	ENSCAFP00000031585	ENSCAFP00000052790	Nuclear factor of activated T cells 1.	Nuclear factor of activated T cells 3.	0.921
NFATC1	SRF	ENSCAFP00000031585	ENSCAFP00000002675	Nuclear factor of activated T cells 1.	Serum response factor.	0.908
NFATC2	GATA4	ENSCAFP00000017095	ENSCAFP00000038219	Nuclear factor of activated T cells 2.	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	0.919
NFATC2	NFATC1	ENSCAFP00000017095	ENSCAFP00000031585	Nuclear factor of activated T cells 2.	Nuclear factor of activated T cells 1.	0.937
NFATC2	NFATC3	ENSCAFP00000017095	ENSCAFP00000052790	Nuclear factor of activated T cells 2.	Nuclear factor of activated T cells 3.	0.933
NFATC2	NFATC4	ENSCAFP00000017095	ENSCAFP00000039115	Nuclear factor of activated T cells 2.	Nuclear factor of activated T cells 4.	0.919