SPINK4 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SPINK4

Serine peptidase inhibitor, Kazal type 4. (95 aa)

Predicted Functional Partners:

TAGAP

0.534

SPINK1

0.498

SPINK13

0.485

LOC480786

0.460

LOC475818

0.460

LOC491520

0.460

GUCA2A

0.458

SPDEF

0.431

SPINK5

0.413

NFX1

0.412

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GUCA2A	SPINK4	ENSCAFP00000003737	ENSCAFP00000002693	Guanylate cyclase activator 2A.	Serine peptidase inhibitor, Kazal type 4.	0.458
LOC475818	SPINK4	ENSCAFP00000058763	ENSCAFP00000002693	C-type lectin domain-containing protein.	Serine peptidase inhibitor, Kazal type 4.	0.460
LOC480786	SPINK4	ENSCAFP00000021344	ENSCAFP00000002693	C-type lectin domain-containing protein.	Serine peptidase inhibitor, Kazal type 4.	0.460
LOC491520	SPINK4	ENSCAFP00000062633	ENSCAFP00000002693	C-type lectin domain-containing protein.	Serine peptidase inhibitor, Kazal type 4.	0.460
NFX1	SPINK4	ENSCAFP00000002702	ENSCAFP00000002693	Nuclear transcription factor, X-box binding 1.	Serine peptidase inhibitor, Kazal type 4.	0.412
SPDEF	SPINK4	ENSCAFP00000001756	ENSCAFP00000002693	SAM pointed domain containing ETS transcription factor.	Serine peptidase inhibitor, Kazal type 4.	0.431
SPINK1	SPINK4	ENSCAFP00000009934	ENSCAFP00000002693	Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin- catalyzed premature activation of zymogens (By similarity).	Serine peptidase inhibitor, Kazal type 4.	0.498
SPINK13	SPINK4	ENSCAFP00000048638	ENSCAFP00000002693	Kazal-like domain-containing protein.	Serine peptidase inhibitor, Kazal type 4.	0.485
SPINK13	SPINK5	ENSCAFP00000048638	ENSCAFP00000009965	Kazal-like domain-containing protein.	Serine peptidase inhibitor, Kazal type 5.	0.402
SPINK4	GUCA2A	ENSCAFP00000002693	ENSCAFP00000003737	Serine peptidase inhibitor, Kazal type 4.	Guanylate cyclase activator 2A.	0.458
SPINK4	LOC475818	ENSCAFP00000002693	ENSCAFP00000058763	Serine peptidase inhibitor, Kazal type 4.	C-type lectin domain-containing protein.	0.460
SPINK4	LOC480786	ENSCAFP00000002693	ENSCAFP00000021344	Serine peptidase inhibitor, Kazal type 4.	C-type lectin domain-containing protein.	0.460
SPINK4	LOC491520	ENSCAFP00000002693	ENSCAFP00000062633	Serine peptidase inhibitor, Kazal type 4.	C-type lectin domain-containing protein.	0.460
SPINK4	NFX1	ENSCAFP00000002693	ENSCAFP00000002702	Serine peptidase inhibitor, Kazal type 4.	Nuclear transcription factor, X-box binding 1.	0.412
SPINK4	SPDEF	ENSCAFP00000002693	ENSCAFP00000001756	Serine peptidase inhibitor, Kazal type 4.	SAM pointed domain containing ETS transcription factor.	0.431
SPINK4	SPINK1	ENSCAFP00000002693	ENSCAFP00000009934	Serine peptidase inhibitor, Kazal type 4.	Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin- catalyzed premature activation of zymogens (By similarity).	0.498
SPINK4	SPINK13	ENSCAFP00000002693	ENSCAFP00000048638	Serine peptidase inhibitor, Kazal type 4.	Kazal-like domain-containing protein.	0.485
SPINK4	SPINK5	ENSCAFP00000002693	ENSCAFP00000009965	Serine peptidase inhibitor, Kazal type 4.	Serine peptidase inhibitor, Kazal type 5.	0.413
SPINK4	TAGAP	ENSCAFP00000002693	ENSCAFP00000000946	Serine peptidase inhibitor, Kazal type 4.	T cell activation RhoGTPase activating protein.	0.534
SPINK5	SPINK13	ENSCAFP00000009965	ENSCAFP00000048638	Serine peptidase inhibitor, Kazal type 5.	Kazal-like domain-containing protein.	0.402