STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BAG1BCL2 associated athanogene 1. (458 aa)    
Predicted Functional Partners:
BAG2
BCL2 associated athanogene 2.
     
 0.978
BCL2
Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).
    
 
 0.963
HSPBP1
HSPA (Hsp70) binding protein 1.
   
 
 0.955
HSPA4L
Heat shock protein family A (Hsp70) member 4 like.
    
 0.945
HSPH1
Heat shock protein family H (Hsp110) member 1.
    
 0.945
HSPA8
Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family.
   
 0.943
H9GW49_CANLF
Uncharacterized protein; Belongs to the heat shock protein 70 family.
    
 
 0.908
ENSCAFP00000057669
Uncharacterized protein.
    
 
 0.908
ENSCAFP00000059347
Uncharacterized protein; Belongs to the heat shock protein 70 family.
    
 
 0.908
ENSCAFP00000064496
Uncharacterized protein.
    
 
 0.908
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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