APBA1 protein (Canis lupus familiaris) - STRING interaction network

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Score

APBA1

Amyloid beta precursor protein binding family A member 1. (929 aa)

Predicted Functional Partners:

CASK

0.915

SLC18B1

0.911

LIN7A

0.906

APP

0.900

LIN7C

0.879

LIN7B

0.879

STXBP2

0.865

ASTL

0.694

PSEN1

0.662

CTCF

0.661

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBA1	APP	ENSCAFP00000002781	ENSCAFP00000012583	Amyloid beta precursor protein binding family A member 1.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.900
APBA1	ASTL	ENSCAFP00000002781	ENSCAFP00000045771	Amyloid beta precursor protein binding family A member 1.	Metalloendopeptidase.	0.694
APBA1	CASK	ENSCAFP00000002781	ENSCAFP00000044853	Amyloid beta precursor protein binding family A member 1.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.915
APBA1	CTCF	ENSCAFP00000002781	ENSCAFP00000030188	Amyloid beta precursor protein binding family A member 1.	CCCTC-binding factor.	0.661
APBA1	LIN7A	ENSCAFP00000002781	ENSCAFP00000062478	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.906
APBA1	LIN7B	ENSCAFP00000002781	ENSCAFP00000050073	Amyloid beta precursor protein binding family A member 1.	Lin-7 homolog B, crumbs cell polarity complex component.	0.879
APBA1	LIN7C	ENSCAFP00000002781	ENSCAFP00000014981	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.879
APBA1	PSEN1	ENSCAFP00000002781	ENSCAFP00000024732	Amyloid beta precursor protein binding family A member 1.	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...]	0.662
APBA1	SLC18B1	ENSCAFP00000002781	ENSCAFP00000042619	Amyloid beta precursor protein binding family A member 1.	Solute carrier family 18 member B1.	0.911
APBA1	STXBP2	ENSCAFP00000002781	ENSCAFP00000027039	Amyloid beta precursor protein binding family A member 1.	Syntaxin-binding protein 2; Involved in the protein trafficking from the Golgi apparatus to the plasma membrane; Belongs to the STXBP/unc-18/SEC1 family.	0.865
APP	APBA1	ENSCAFP00000012583	ENSCAFP00000002781	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Amyloid beta precursor protein binding family A member 1.	0.900
APP	PSEN1	ENSCAFP00000012583	ENSCAFP00000024732	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...]	0.996
ASTL	APBA1	ENSCAFP00000045771	ENSCAFP00000002781	Metalloendopeptidase.	Amyloid beta precursor protein binding family A member 1.	0.694
CASK	APBA1	ENSCAFP00000044853	ENSCAFP00000002781	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Amyloid beta precursor protein binding family A member 1.	0.915
CASK	LIN7A	ENSCAFP00000044853	ENSCAFP00000062478	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.944
CASK	LIN7B	ENSCAFP00000044853	ENSCAFP00000050073	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Lin-7 homolog B, crumbs cell polarity complex component.	0.808
CASK	LIN7C	ENSCAFP00000044853	ENSCAFP00000014981	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.808
CASK	SLC18B1	ENSCAFP00000044853	ENSCAFP00000042619	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Solute carrier family 18 member B1.	0.520
CTCF	APBA1	ENSCAFP00000030188	ENSCAFP00000002781	CCCTC-binding factor.	Amyloid beta precursor protein binding family A member 1.	0.661
CTCF	SLC18B1	ENSCAFP00000030188	ENSCAFP00000042619	CCCTC-binding factor.	Solute carrier family 18 member B1.	0.713