Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
COMMD8COMM domain containing 8. (183 aa)    
Predicted Functional Partners:
COMMD5
COMM domain containing 5.
   
 0.996
COMMD4
COMM domain containing 4.
   
 0.996
CCDC22
Coiled-coil domain containing 22.
    
 0.994
COMMD2
COMM domain containing 2.
   
 
 0.993
COMMD10
COMM domain containing 10.
   
 0.991
COMMD6
COMM domain containing 6.
   
 0.991
COMMD9
COMM domain containing 9.
   
 0.989
CCDC93
Coiled-coil domain containing 93.
   
 
 0.983
COMMD1
COMM domain-containing protein 1; Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF- kappa-B activity. Involved in the regulation of membrane expression and ubiquiti [...]
   
 
 0.981
DENND10
Family with sequence similarity 45 member A.
    
 
 0.976
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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