HSP90AB1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HSP90AB1

Heat shock protein 90 alpha family class B member 1. (724 aa)

Predicted Functional Partners:

SUGT1

0.982

CDC37

0.950

HSPA4

0.910

FKBP4

0.908

STIP1

0.905

HSPA5

0.879

HSPA2

0.870

HSP90B1

0.868

AHR

0.854

PPID

0.849

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHR	HSP90AB1	ENSCAFP00000052303	ENSCAFP00000002914	Aryl hydrocarbon receptor.	Heat shock protein 90 alpha family class B member 1.	0.854
CDC37	FKBP4	ENSCAFP00000057351	ENSCAFP00000022946	Cell division cycle 37.	Peptidylprolyl isomerase.	0.811
CDC37	HSP90AB1	ENSCAFP00000057351	ENSCAFP00000002914	Cell division cycle 37.	Heat shock protein 90 alpha family class B member 1.	0.950
CDC37	HSP90B1	ENSCAFP00000057351	ENSCAFP00000057899	Cell division cycle 37.	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	0.986
CDC37	HSPA4	ENSCAFP00000057351	ENSCAFP00000062263	Cell division cycle 37.	Heat shock 70 kDa protein 4.	0.633
CDC37	PPID	ENSCAFP00000057351	ENSCAFP00000012766	Cell division cycle 37.	Peptidylprolyl isomerase D.	0.586
CDC37	STIP1	ENSCAFP00000057351	ENSCAFP00000061401	Cell division cycle 37.	Stress induced phosphoprotein 1.	0.957
CDC37	SUGT1	ENSCAFP00000057351	ENSCAFP00000007201	Cell division cycle 37.	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.566
FKBP4	CDC37	ENSCAFP00000022946	ENSCAFP00000057351	Peptidylprolyl isomerase.	Cell division cycle 37.	0.811
FKBP4	HSP90AB1	ENSCAFP00000022946	ENSCAFP00000002914	Peptidylprolyl isomerase.	Heat shock protein 90 alpha family class B member 1.	0.908
FKBP4	HSPA2	ENSCAFP00000022946	ENSCAFP00000023616	Peptidylprolyl isomerase.	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	0.585
FKBP4	HSPA4	ENSCAFP00000022946	ENSCAFP00000062263	Peptidylprolyl isomerase.	Heat shock 70 kDa protein 4.	0.614
FKBP4	STIP1	ENSCAFP00000022946	ENSCAFP00000061401	Peptidylprolyl isomerase.	Stress induced phosphoprotein 1.	0.971
FKBP4	SUGT1	ENSCAFP00000022946	ENSCAFP00000007201	Peptidylprolyl isomerase.	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.677
HSP90AB1	AHR	ENSCAFP00000002914	ENSCAFP00000052303	Heat shock protein 90 alpha family class B member 1.	Aryl hydrocarbon receptor.	0.854
HSP90AB1	CDC37	ENSCAFP00000002914	ENSCAFP00000057351	Heat shock protein 90 alpha family class B member 1.	Cell division cycle 37.	0.950
HSP90AB1	FKBP4	ENSCAFP00000002914	ENSCAFP00000022946	Heat shock protein 90 alpha family class B member 1.	Peptidylprolyl isomerase.	0.908
HSP90AB1	HSP90B1	ENSCAFP00000002914	ENSCAFP00000057899	Heat shock protein 90 alpha family class B member 1.	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	0.868
HSP90AB1	HSPA2	ENSCAFP00000002914	ENSCAFP00000023616	Heat shock protein 90 alpha family class B member 1.	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	0.870
HSP90AB1	HSPA4	ENSCAFP00000002914	ENSCAFP00000062263	Heat shock protein 90 alpha family class B member 1.	Heat shock 70 kDa protein 4.	0.910