STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNFRSF21Uncharacterized protein. (623 aa)    
Predicted Functional Partners:
APP
Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]
    
 
 0.736
TRADD
TNFRSF1A associated via death domain.
    
 
 0.569
APLP2
Amyloid beta precursor like protein 2.
    
 
 0.551
TNFRSF25
TNF receptor superfamily member 25.
   
  
 0.518
SSR3
Signal sequence receptor subunit 3.
      
 0.511
RAB3IP
RAB3A interacting protein.
      
 0.499
FASLG
Tumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family.
      
 0.497
ACSF2
Acyl-CoA synthetase family member 2.
   
  
 0.489
CSDE1
Cold shock domain containing E1.
      
 0.489
MTRF1L
Mitochondrial translational release factor 1 like.
      
 0.487
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (24%) [HD]