| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CTNNB1 | EGFR | ENSCAFP00000007783 | ENSCAFP00000005164 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Receptor protein-tyrosine kinase. | 0.986 |
| CTNNB1 | FHL2 | ENSCAFP00000007783 | ENSCAFP00000003094 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Four and a half LIM domains 2. | 0.943 |
| CTNNB1 | LEF1 | ENSCAFP00000007783 | ENSCAFP00000056485 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Lymphoid enhancer binding factor 1. | 0.999 |
| CTNNB1 | TRAF6 | ENSCAFP00000007783 | ENSCAFP00000010159 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.415 |
| EGFR | CTNNB1 | ENSCAFP00000005164 | ENSCAFP00000007783 | Receptor protein-tyrosine kinase. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | 0.986 |
| EGFR | FHL2 | ENSCAFP00000005164 | ENSCAFP00000003094 | Receptor protein-tyrosine kinase. | Four and a half LIM domains 2. | 0.574 |
| EGFR | TRAF6 | ENSCAFP00000005164 | ENSCAFP00000010159 | Receptor protein-tyrosine kinase. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.829 |
| FHL2 | CTNNB1 | ENSCAFP00000003094 | ENSCAFP00000007783 | Four and a half LIM domains 2. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | 0.943 |
| FHL2 | EGFR | ENSCAFP00000003094 | ENSCAFP00000005164 | Four and a half LIM domains 2. | Receptor protein-tyrosine kinase. | 0.574 |
| FHL2 | KCNE1 | ENSCAFP00000003094 | ENSCAFP00000014038 | Four and a half LIM domains 2. | Uncharacterized protein. | 0.565 |
| FHL2 | LEF1 | ENSCAFP00000003094 | ENSCAFP00000056485 | Four and a half LIM domains 2. | Lymphoid enhancer binding factor 1. | 0.803 |
| FHL2 | LIMD2 | ENSCAFP00000003094 | ENSCAFP00000019039 | Four and a half LIM domains 2. | LIM domain containing 2. | 0.677 |
| FHL2 | STX11 | ENSCAFP00000003094 | ENSCAFP00000051697 | Four and a half LIM domains 2. | Syntaxin 11; Belongs to the syntaxin family. | 0.682 |
| FHL2 | STXBP2 | ENSCAFP00000003094 | ENSCAFP00000027039 | Four and a half LIM domains 2. | Syntaxin-binding protein 2; Involved in the protein trafficking from the Golgi apparatus to the plasma membrane; Belongs to the STXBP/unc-18/SEC1 family. | 0.685 |
| FHL2 | TCAP | ENSCAFP00000003094 | ENSCAFP00000044397 | Four and a half LIM domains 2. | Titin-cap. | 0.569 |
| FHL2 | TRAF2 | ENSCAFP00000003094 | ENSCAFP00000028895 | Four and a half LIM domains 2. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.910 |
| FHL2 | TRAF6 | ENSCAFP00000003094 | ENSCAFP00000010159 | Four and a half LIM domains 2. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.918 |
| KCNE1 | FHL2 | ENSCAFP00000014038 | ENSCAFP00000003094 | Uncharacterized protein. | Four and a half LIM domains 2. | 0.565 |
| KCNE1 | LIMD2 | ENSCAFP00000014038 | ENSCAFP00000019039 | Uncharacterized protein. | LIM domain containing 2. | 0.665 |
| KCNE1 | TCAP | ENSCAFP00000014038 | ENSCAFP00000044397 | Uncharacterized protein. | Titin-cap. | 0.477 |