| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRCA1 | CTNNB1 | ENSCAFP00000048759 | ENSCAFP00000007783 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | 0.528 |
| BRCA1 | EGFR | ENSCAFP00000048759 | ENSCAFP00000005164 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Receptor protein-tyrosine kinase. | 0.601 |
| BRCA1 | FHL2 | ENSCAFP00000048759 | ENSCAFP00000003094 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Four and a half LIM domains 2. | 0.754 |
| CNOT1 | CNOT2 | ENSCAFP00000012418 | ENSCAFP00000056484 | CCR4-NOT transcription complex subunit 1. | CCR4-NOT transcription complex subunit 2. | 0.988 |
| CNOT1 | FHL2 | ENSCAFP00000012418 | ENSCAFP00000003094 | CCR4-NOT transcription complex subunit 1. | Four and a half LIM domains 2. | 0.790 |
| CNOT2 | CNOT1 | ENSCAFP00000056484 | ENSCAFP00000012418 | CCR4-NOT transcription complex subunit 2. | CCR4-NOT transcription complex subunit 1. | 0.988 |
| CNOT2 | FHL2 | ENSCAFP00000056484 | ENSCAFP00000003094 | CCR4-NOT transcription complex subunit 2. | Four and a half LIM domains 2. | 0.801 |
| CTNNB1 | BRCA1 | ENSCAFP00000007783 | ENSCAFP00000048759 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.528 |
| CTNNB1 | EGFR | ENSCAFP00000007783 | ENSCAFP00000005164 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Receptor protein-tyrosine kinase. | 0.994 |
| CTNNB1 | FHL2 | ENSCAFP00000007783 | ENSCAFP00000003094 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Four and a half LIM domains 2. | 0.732 |
| CTNNB1 | TRAF6 | ENSCAFP00000007783 | ENSCAFP00000010159 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.712 |
| EGFR | BRCA1 | ENSCAFP00000005164 | ENSCAFP00000048759 | Receptor protein-tyrosine kinase. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.601 |
| EGFR | CTNNB1 | ENSCAFP00000005164 | ENSCAFP00000007783 | Receptor protein-tyrosine kinase. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | 0.994 |
| EGFR | FHL2 | ENSCAFP00000005164 | ENSCAFP00000003094 | Receptor protein-tyrosine kinase. | Four and a half LIM domains 2. | 0.824 |
| EGFR | TRAF1 | ENSCAFP00000005164 | ENSCAFP00000031262 | Receptor protein-tyrosine kinase. | TNF receptor associated factor 1. | 0.751 |
| EGFR | TRAF2 | ENSCAFP00000005164 | ENSCAFP00000028895 | Receptor protein-tyrosine kinase. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.748 |
| EGFR | TRAF6 | ENSCAFP00000005164 | ENSCAFP00000010159 | Receptor protein-tyrosine kinase. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.918 |
| FHL1 | FHL2 | ENSCAFP00000027932 | ENSCAFP00000003094 | Four and a half LIM domains 1. | Four and a half LIM domains 2. | 0.892 |
| FHL1 | FHL3 | ENSCAFP00000027932 | ENSCAFP00000004781 | Four and a half LIM domains 1. | Four and a half LIM domains 3. | 0.887 |
| FHL2 | BRCA1 | ENSCAFP00000003094 | ENSCAFP00000048759 | Four and a half LIM domains 2. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.754 |
