STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PLGRKTPlasminogen receptor with a C-terminal lysine. (147 aa)    
Predicted Functional Partners:
PLG
Plasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...]
    
 
 0.728
ITM2C
Integral membrane protein 2C.
      
 0.669
MFSD10
Major facilitator superfamily domain containing 10.
   
  
 0.627
HPN
Hepsin; Belongs to the peptidase S1 family.
    
 
 0.563
TSPAN13
Tetraspanin 13; Belongs to the tetraspanin (TM4SF) family.
      
 0.535
SUOX
Sulfite oxidase.
      
 0.519
ARL14EP
ADP ribosylation factor like GTPase 14 effector protein.
   
  
 0.512
NAPSA
Napsin A aspartic peptidase; Belongs to the peptidase A1 family.
      
 0.479
TGFBRAP1
Transforming growth factor beta receptor associated protein 1.
      
 0.473
TMPRSS4
Transmembrane serine protease 4; Belongs to the peptidase S1 family.
    
 
 0.472
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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