IL1R2 protein (Canis lupus familiaris) - STRING interaction network

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Score

IL1R2

Interleukin 1 receptor type 2. (595 aa)

Predicted Functional Partners:

IL1B

0.990

IL1A

0.983

IL1RN

0.946

IL1RAP

0.892

IL1R1

0.867

IL36RN

0.842

IL18RAP

0.819

IL1RL2

0.793

EXOC6B

0.769

EXOC8

0.769

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EXOC6B	EXOC8	ENSCAFP00000013203	ENSCAFP00000017348	Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.	Exocyst complex component 8.	0.996
EXOC6B	IL1R2	ENSCAFP00000013203	ENSCAFP00000003143	Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.	Interleukin 1 receptor type 2.	0.769
EXOC8	EXOC6B	ENSCAFP00000017348	ENSCAFP00000013203	Exocyst complex component 8.	Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.	0.996
EXOC8	IL1R2	ENSCAFP00000017348	ENSCAFP00000003143	Exocyst complex component 8.	Interleukin 1 receptor type 2.	0.769
IL18RAP	IL1A	ENSCAFP00000003121	ENSCAFP00000038305	Interleukin 18 receptor accessory protein.	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).	0.608
IL18RAP	IL1B	ENSCAFP00000003121	ENSCAFP00000010762	Interleukin 18 receptor accessory protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.873
IL18RAP	IL1R1	ENSCAFP00000003121	ENSCAFP00000046086	Interleukin 18 receptor accessory protein.	Interleukin 1 receptor type 1.	0.534
IL18RAP	IL1R2	ENSCAFP00000003121	ENSCAFP00000003143	Interleukin 18 receptor accessory protein.	Interleukin 1 receptor type 2.	0.819
IL18RAP	IL1RL2	ENSCAFP00000003121	ENSCAFP00000003133	Interleukin 18 receptor accessory protein.	Interleukin 1 receptor like 2.	0.534
IL18RAP	IL1RN	ENSCAFP00000003121	ENSCAFP00000036995	Interleukin 18 receptor accessory protein.	Interleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity (By similarity). Belongs to the IL-1 family.	0.568
IL18RAP	IL36RN	ENSCAFP00000003121	ENSCAFP00000010784	Interleukin 18 receptor accessory protein.	Interleukin-1.	0.402
IL1A	IL18RAP	ENSCAFP00000038305	ENSCAFP00000003121	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).	Interleukin 18 receptor accessory protein.	0.608
IL1A	IL1B	ENSCAFP00000038305	ENSCAFP00000010762	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.999
IL1A	IL1R1	ENSCAFP00000038305	ENSCAFP00000046086	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).	Interleukin 1 receptor type 1.	0.968
IL1A	IL1R2	ENSCAFP00000038305	ENSCAFP00000003143	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).	Interleukin 1 receptor type 2.	0.983
IL1A	IL1RAP	ENSCAFP00000038305	ENSCAFP00000020672	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).	Interleukin 1 receptor accessory protein.	0.950
IL1A	IL1RL2	ENSCAFP00000038305	ENSCAFP00000003133	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).	Interleukin 1 receptor like 2.	0.933
IL1A	IL1RN	ENSCAFP00000038305	ENSCAFP00000036995	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).	Interleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity (By similarity). Belongs to the IL-1 family.	0.836
IL1A	IL36RN	ENSCAFP00000038305	ENSCAFP00000010784	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).	Interleukin-1.	0.712
IL1B	IL18RAP	ENSCAFP00000010762	ENSCAFP00000003121	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Interleukin 18 receptor accessory protein.	0.873