Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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NFIL3Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...] (462 aa)    
Predicted Functional Partners:
NR1D2
Nuclear receptor subfamily 1 group D member 2.
   
 0.908
NR1D1
Nuclear receptor subfamily 1 group D member 1.
   
 0.903
RORA
RAR related orphan receptor A.
    
 0.898
RORB
RAR related orphan receptor B.
    
 0.883
RORC
RAR related orphan receptor C.
    
 0.881
PER2
Period circadian regulator 2.
   
 0.878
PER1
Period circadian regulator 1.
   
 0.838
PER3
Period circadian regulator 3.
   
 0.823
IL3
Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family.
    
 
 0.783
HLF
HLF transcription factor, PAR bZIP family member.
    
 
0.782
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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