PKHD1 protein (Canis lupus familiaris) - STRING interaction network

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PKHD1

PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4074 aa)

Predicted Functional Partners:

PKD2

0.793

NPHP3

0.578

RP1L1

0.554

ARL13B

0.553

AHDC1

0.552

TMIGD1

0.537

SACS

0.527

NPHP1

0.520

TULP3

0.518

GPR161

0.495

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHDC1	PKHD1	ENSCAFP00000041469	ENSCAFP00000003171	AT-hook DNA binding motif containing 1.	PKHD1 ciliary IPT domain containing fibrocystin/polyductin.	0.552
ARL13B	GPR161	ENSCAFP00000013262	ENSCAFP00000022573	ADP ribosylation factor like GTPase 13B.	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.738
ARL13B	NPHP1	ENSCAFP00000013262	ENSCAFP00000010483	ADP ribosylation factor like GTPase 13B.	Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly (By similarity). Required for n [...]	0.717
ARL13B	NPHP3	ENSCAFP00000013262	ENSCAFP00000066560	ADP ribosylation factor like GTPase 13B.	Nephrocystin 3.	0.667
ARL13B	PKD2	ENSCAFP00000013262	ENSCAFP00000014105	ADP ribosylation factor like GTPase 13B.	Polycystin 2, transient receptor potential cation channel.	0.778
ARL13B	PKHD1	ENSCAFP00000013262	ENSCAFP00000003171	ADP ribosylation factor like GTPase 13B.	PKHD1 ciliary IPT domain containing fibrocystin/polyductin.	0.553
ARL13B	TULP3	ENSCAFP00000013262	ENSCAFP00000022958	ADP ribosylation factor like GTPase 13B.	Tubby-like protein; Belongs to the TUB family.	0.692
GPR161	ARL13B	ENSCAFP00000022573	ENSCAFP00000013262	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	ADP ribosylation factor like GTPase 13B.	0.738
GPR161	PKHD1	ENSCAFP00000022573	ENSCAFP00000003171	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	PKHD1 ciliary IPT domain containing fibrocystin/polyductin.	0.495
GPR161	TULP3	ENSCAFP00000022573	ENSCAFP00000022958	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	Tubby-like protein; Belongs to the TUB family.	0.837
NPHP1	ARL13B	ENSCAFP00000010483	ENSCAFP00000013262	Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly (By similarity). Required for n [...]	ADP ribosylation factor like GTPase 13B.	0.717
NPHP1	NPHP3	ENSCAFP00000010483	ENSCAFP00000066560	Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly (By similarity). Required for n [...]	Nephrocystin 3.	0.816
NPHP1	PKD2	ENSCAFP00000010483	ENSCAFP00000014105	Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly (By similarity). Required for n [...]	Polycystin 2, transient receptor potential cation channel.	0.416
NPHP1	PKHD1	ENSCAFP00000010483	ENSCAFP00000003171	Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly (By similarity). Required for n [...]	PKHD1 ciliary IPT domain containing fibrocystin/polyductin.	0.520
NPHP3	ARL13B	ENSCAFP00000066560	ENSCAFP00000013262	Nephrocystin 3.	ADP ribosylation factor like GTPase 13B.	0.667
NPHP3	NPHP1	ENSCAFP00000066560	ENSCAFP00000010483	Nephrocystin 3.	Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly (By similarity). Required for n [...]	0.816
NPHP3	PKD2	ENSCAFP00000066560	ENSCAFP00000014105	Nephrocystin 3.	Polycystin 2, transient receptor potential cation channel.	0.532
NPHP3	PKHD1	ENSCAFP00000066560	ENSCAFP00000003171	Nephrocystin 3.	PKHD1 ciliary IPT domain containing fibrocystin/polyductin.	0.578
PKD2	ARL13B	ENSCAFP00000014105	ENSCAFP00000013262	Polycystin 2, transient receptor potential cation channel.	ADP ribosylation factor like GTPase 13B.	0.778
PKD2	NPHP1	ENSCAFP00000014105	ENSCAFP00000010483	Polycystin 2, transient receptor potential cation channel.	Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly (By similarity). Required for n [...]	0.416