node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGFR | ERBB2 | ENSCAFP00000005164 | ENSCAFP00000024079 | Receptor protein-tyrosine kinase. | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | 0.997 |
EGFR | ERBB3 | ENSCAFP00000005164 | ENSCAFP00000000139 | Receptor protein-tyrosine kinase. | Erb-b2 receptor tyrosine kinase 3. | 0.979 |
EGFR | ERBB4 | ENSCAFP00000005164 | ENSCAFP00000048210 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.888 |
EGFR | GRB2 | ENSCAFP00000005164 | ENSCAFP00000049390 | Receptor protein-tyrosine kinase. | Growth factor receptor bound protein 2. | 0.999 |
EGFR | IGF1R | ENSCAFP00000005164 | ENSCAFP00000043796 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase receptor. | 0.676 |
EGFR | SHC3 | ENSCAFP00000005164 | ENSCAFP00000003204 | Receptor protein-tyrosine kinase. | SHC adaptor protein 3. | 0.976 |
EGFR | SOS1 | ENSCAFP00000005164 | ENSCAFP00000009512 | Receptor protein-tyrosine kinase. | SOS Ras/Rac guanine nucleotide exchange factor 1. | 0.996 |
EGFR | SOS2 | ENSCAFP00000005164 | ENSCAFP00000021080 | Receptor protein-tyrosine kinase. | SOS Ras/Rho guanine nucleotide exchange factor 2. | 0.977 |
EGFR | SRC | ENSCAFP00000005164 | ENSCAFP00000044994 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase. | 0.989 |
ERBB2 | EGFR | ENSCAFP00000024079 | ENSCAFP00000005164 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | Receptor protein-tyrosine kinase. | 0.997 |
ERBB2 | ERBB3 | ENSCAFP00000024079 | ENSCAFP00000000139 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | Erb-b2 receptor tyrosine kinase 3. | 0.998 |
ERBB2 | ERBB4 | ENSCAFP00000024079 | ENSCAFP00000048210 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | Receptor protein-tyrosine kinase. | 0.991 |
ERBB2 | GRB2 | ENSCAFP00000024079 | ENSCAFP00000049390 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | Growth factor receptor bound protein 2. | 0.991 |
ERBB2 | IGF1R | ENSCAFP00000024079 | ENSCAFP00000043796 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | Tyrosine-protein kinase receptor. | 0.793 |
ERBB2 | SHC3 | ENSCAFP00000024079 | ENSCAFP00000003204 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | SHC adaptor protein 3. | 0.963 |
ERBB2 | SOS1 | ENSCAFP00000024079 | ENSCAFP00000009512 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | SOS Ras/Rac guanine nucleotide exchange factor 1. | 0.757 |
ERBB2 | SOS2 | ENSCAFP00000024079 | ENSCAFP00000021080 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | SOS Ras/Rho guanine nucleotide exchange factor 2. | 0.534 |
ERBB2 | SRC | ENSCAFP00000024079 | ENSCAFP00000044994 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | Tyrosine-protein kinase. | 0.964 |
ERBB3 | EGFR | ENSCAFP00000000139 | ENSCAFP00000005164 | Erb-b2 receptor tyrosine kinase 3. | Receptor protein-tyrosine kinase. | 0.979 |
ERBB3 | ERBB2 | ENSCAFP00000000139 | ENSCAFP00000024079 | Erb-b2 receptor tyrosine kinase 3. | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | 0.998 |