STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHC3SHC adaptor protein 3. (458 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
   
 0.980
EGFR
Receptor protein-tyrosine kinase.
    
 0.976
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
   
 0.965
ERBB2
Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]
    
 0.963
NTRK3
Tyrosine-protein kinase receptor.
   
 0.963
SRC
Tyrosine-protein kinase.
   
 0.960
ERBB3
Erb-b2 receptor tyrosine kinase 3.
    
 0.958
ERBB4
Receptor protein-tyrosine kinase.
    
 0.958
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2.
   
 0.956
IGF1R
Tyrosine-protein kinase receptor.
    
 0.955
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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