SHC3 protein (Canis lupus familiaris) - STRING interaction network

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Score

SHC3

SHC adaptor protein 3. (458 aa)

Predicted Functional Partners:

GRB2

0.988

SOS1

0.987

EGFR

0.977

ERBB2

0.973

GAB1

0.970

INSR

0.969

IGF1R

0.969

NTRK2

0.962

SOS2

0.961

NTRK3

0.959

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB2	ENSCAFP00000005164	ENSCAFP00000024079	Receptor protein-tyrosine kinase.	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	0.994
EGFR	GAB1	ENSCAFP00000005164	ENSCAFP00000005384	Receptor protein-tyrosine kinase.	GRB2 associated binding protein 1.	0.996
EGFR	GRB2	ENSCAFP00000005164	ENSCAFP00000049390	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.999
EGFR	IGF1R	ENSCAFP00000005164	ENSCAFP00000043796	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.946
EGFR	INSR	ENSCAFP00000005164	ENSCAFP00000038176	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.868
EGFR	NTRK2	ENSCAFP00000005164	ENSCAFP00000063233	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.877
EGFR	NTRK3	ENSCAFP00000005164	ENSCAFP00000043465	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.779
EGFR	SHC3	ENSCAFP00000005164	ENSCAFP00000003204	Receptor protein-tyrosine kinase.	SHC adaptor protein 3.	0.977
EGFR	SOS1	ENSCAFP00000005164	ENSCAFP00000009512	Receptor protein-tyrosine kinase.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.997
EGFR	SOS2	ENSCAFP00000005164	ENSCAFP00000021080	Receptor protein-tyrosine kinase.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.993
ERBB2	EGFR	ENSCAFP00000024079	ENSCAFP00000005164	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Receptor protein-tyrosine kinase.	0.994
ERBB2	GAB1	ENSCAFP00000024079	ENSCAFP00000005384	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	GRB2 associated binding protein 1.	0.950
ERBB2	GRB2	ENSCAFP00000024079	ENSCAFP00000049390	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Growth factor receptor bound protein 2.	0.994
ERBB2	IGF1R	ENSCAFP00000024079	ENSCAFP00000043796	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Tyrosine-protein kinase receptor.	0.963
ERBB2	INSR	ENSCAFP00000024079	ENSCAFP00000038176	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Tyrosine-protein kinase receptor.	0.931
ERBB2	NTRK2	ENSCAFP00000024079	ENSCAFP00000063233	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Tyrosine-protein kinase receptor.	0.780
ERBB2	NTRK3	ENSCAFP00000024079	ENSCAFP00000043465	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Tyrosine-protein kinase receptor.	0.893
ERBB2	SHC3	ENSCAFP00000024079	ENSCAFP00000003204	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	SHC adaptor protein 3.	0.973
ERBB2	SOS1	ENSCAFP00000024079	ENSCAFP00000009512	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.836
ERBB2	SOS2	ENSCAFP00000024079	ENSCAFP00000021080	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.822