STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CREB3cAMP responsive element binding protein 3. (353 aa)    
Predicted Functional Partners:
CREBRF
CREB3 regulatory factor.
    
 0.951
HCFC2
Host cell factor C2.
    
 
 0.803
MBTPS1
Membrane bound transcription factor peptidase, site 1.
   
 
 0.796
HCFC1
Host cell factor C1.
    
 
 0.789
ZBTB33
Zinc finger and BTB domain containing 33.
      
 0.677
DNAJC11
DnaJ heat shock protein family (Hsp40) member C11.
      
 0.648
CREB1
cAMP responsive element binding protein 1.
   
 
 0.581
GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity).
      
 0.573
CDC42SE1
CDC42 small effector 1.
   
  
 0.542
FZD4
Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.
   
  
 0.534
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.