STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RGP1RGP1 homolog, RAB6A GEF complex partner 1. (445 aa)    
Predicted Functional Partners:
RIC1
RIC1 homolog, RAB6A GEF complex partner 1.
    
 0.982
RAB6A
RAB6A, member RAS oncogene family.
    
 0.689
RAB6B
RAB6B, member RAS oncogene family.
    
 0.689
C1S
Complement C1s; Belongs to the peptidase S1 family.
      
 0.673
PDF
Conserved oligomeric Golgi complex subunit 8; Belongs to the COG8 family.
    
 0.646
VPS53
VPS53 subunit of GARP complex.
     
 0.618
VPS52
Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...]
     
 0.601
VPS54
VPS54 subunit of GARP complex.
     
 0.601
COG6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.
    
 0.593
STX16
t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.
    
 0.588
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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