GCLC protein (Canis lupus familiaris) - STRING interaction network

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Score

GCLC

Glutamate-cysteine ligase catalytic subunit. (643 aa)

Predicted Functional Partners:

ANPEP

0.946

GGT6

0.944

GGT1

0.923

GSS

0.918

GGCT

0.908

BCAT1

0.905

AGXT2

0.903

LAP3

0.900

CTH

0.874

NQO1

0.873

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGXT2	BCAT1	ENSCAFP00000052449	ENSCAFP00000064687	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.934
AGXT2	CTH	ENSCAFP00000052449	ENSCAFP00000030288	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Cystathionine gamma-lyase.	0.930
AGXT2	GCLC	ENSCAFP00000052449	ENSCAFP00000003329	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glutamate-cysteine ligase catalytic subunit.	0.903
ANPEP	CTH	ENSCAFP00000017681	ENSCAFP00000030288	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	Cystathionine gamma-lyase.	0.829
ANPEP	GCLC	ENSCAFP00000017681	ENSCAFP00000003329	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	Glutamate-cysteine ligase catalytic subunit.	0.946
ANPEP	GGCT	ENSCAFP00000017681	ENSCAFP00000004578	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	Uncharacterized protein.	0.900
ANPEP	GGT1	ENSCAFP00000017681	ENSCAFP00000055778	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	Uncharacterized protein.	0.941
ANPEP	GGT6	ENSCAFP00000017681	ENSCAFP00000022531	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	Gamma-glutamyltransferase 6.	0.939
ANPEP	GSS	ENSCAFP00000017681	ENSCAFP00000011267	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	Glutathione synthetase.	0.953
ANPEP	LAP3	ENSCAFP00000017681	ENSCAFP00000022254	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	Leucine aminopeptidase 3.	0.948
BCAT1	AGXT2	ENSCAFP00000064687	ENSCAFP00000052449	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.934
BCAT1	CTH	ENSCAFP00000064687	ENSCAFP00000030288	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Cystathionine gamma-lyase.	0.940
BCAT1	GCLC	ENSCAFP00000064687	ENSCAFP00000003329	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Glutamate-cysteine ligase catalytic subunit.	0.905
BCAT1	LAP3	ENSCAFP00000064687	ENSCAFP00000022254	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Leucine aminopeptidase 3.	0.646
CTH	AGXT2	ENSCAFP00000030288	ENSCAFP00000052449	Cystathionine gamma-lyase.	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.930
CTH	ANPEP	ENSCAFP00000030288	ENSCAFP00000017681	Cystathionine gamma-lyase.	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	0.829
CTH	BCAT1	ENSCAFP00000030288	ENSCAFP00000064687	Cystathionine gamma-lyase.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.940
CTH	GCLC	ENSCAFP00000030288	ENSCAFP00000003329	Cystathionine gamma-lyase.	Glutamate-cysteine ligase catalytic subunit.	0.874
CTH	GGCT	ENSCAFP00000030288	ENSCAFP00000004578	Cystathionine gamma-lyase.	Uncharacterized protein.	0.801
CTH	LAP3	ENSCAFP00000030288	ENSCAFP00000022254	Cystathionine gamma-lyase.	Leucine aminopeptidase 3.	0.813