STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM106BTransmembrane protein 106B. (275 aa)    
Predicted Functional Partners:
GRN
Granulin precursor.
      
 0.743
C11H9orf72
Chromosome 11 C9orf72 homolog.
      
 0.731
LAMP1
Lysosomal associated membrane protein 1.
    
 
 0.687
CTSD
Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.
    
 
 0.684
PSAP
Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
      
 0.674
MAP6
Microtubule associated protein 6.
    
 
 0.662
CHMP2B
Charged multivesicular body protein 2B.
   
 
 0.624
SCIN
Scinderin.
 
    
 0.617
TMEM41B
Transmembrane protein 41B.
   
  
 0.606
TANC1
Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1.
    
 
 0.590
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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