node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GALC | HCRTR2 | ENSCAFP00000031633 | ENSCAFP00000003376 | Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (By similarity); Belongs to the glycosyl hydrolase 59 family. | Orexin receptor type 2; Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding; Belongs to the G-protein coupled receptor 1 family. | 0.606 |
GNA15 | GNAQ | ENSCAFP00000028444 | ENSCAFP00000028446 | G protein subunit alpha 15. | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | 0.563 |
GNA15 | GRK2 | ENSCAFP00000028444 | ENSCAFP00000017324 | G protein subunit alpha 15. | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | 0.665 |
GNA15 | HCRT | ENSCAFP00000028444 | ENSCAFP00000022949 | G protein subunit alpha 15. | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. | 0.560 |
GNA15 | HCRTR1 | ENSCAFP00000028444 | ENSCAFP00000059469 | G protein subunit alpha 15. | Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.580 |
GNA15 | HCRTR2 | ENSCAFP00000028444 | ENSCAFP00000003376 | G protein subunit alpha 15. | Orexin receptor type 2; Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding; Belongs to the G-protein coupled receptor 1 family. | 0.580 |
GNAQ | GNA15 | ENSCAFP00000028446 | ENSCAFP00000028444 | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | G protein subunit alpha 15. | 0.563 |
GNAQ | GRK2 | ENSCAFP00000028446 | ENSCAFP00000017324 | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | 0.986 |
GNAQ | HCRT | ENSCAFP00000028446 | ENSCAFP00000022949 | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. | 0.583 |
GNAQ | HCRTR1 | ENSCAFP00000028446 | ENSCAFP00000059469 | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.560 |
GNAQ | HCRTR2 | ENSCAFP00000028446 | ENSCAFP00000003376 | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | Orexin receptor type 2; Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding; Belongs to the G-protein coupled receptor 1 family. | 0.562 |
GRK2 | GNA15 | ENSCAFP00000017324 | ENSCAFP00000028444 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | G protein subunit alpha 15. | 0.665 |
GRK2 | GNAQ | ENSCAFP00000017324 | ENSCAFP00000028446 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | 0.986 |
GRK2 | HCRT | ENSCAFP00000017324 | ENSCAFP00000022949 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. | 0.506 |
GRK2 | HCRTR1 | ENSCAFP00000017324 | ENSCAFP00000059469 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.647 |
GRK2 | HCRTR2 | ENSCAFP00000017324 | ENSCAFP00000003376 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | Orexin receptor type 2; Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding; Belongs to the G-protein coupled receptor 1 family. | 0.647 |
HCRT | GNA15 | ENSCAFP00000022949 | ENSCAFP00000028444 | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. | G protein subunit alpha 15. | 0.560 |
HCRT | GNAQ | ENSCAFP00000022949 | ENSCAFP00000028446 | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | 0.583 |
HCRT | GRK2 | ENSCAFP00000022949 | ENSCAFP00000017324 | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | 0.506 |
HCRT | HCRTR1 | ENSCAFP00000022949 | ENSCAFP00000059469 | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. | Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.981 |