STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RPS5Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. (204 aa)    
Predicted Functional Partners:
RPS12
40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family.
  
 0.999
RPL8
Ribosomal protein L8.
  
 
 0.999
RPL13A
60S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppres [...]
  
 
 0.999
RPS8
40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family.
   
 0.999
RPS3
40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...]
  
 0.999
RPL19
60S ribosomal protein L19.
   
 
 0.999
RPS14
Uncharacterized protein; Belongs to the universal ribosomal protein uS11 family.
  
 0.999
RPS15
Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.
  
 0.999
RPS23
Ribosomal protein S23; Belongs to the universal ribosomal protein uS12 family.
  
 0.999
RPS7
40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family.
   
 0.999
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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