Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FBXO10F-box protein 10. (956 aa)    
Predicted Functional Partners:
CUL1
Cullin 1; Belongs to the cullin family.
   
 0.970
ACSL4
Acyl-CoA synthetase long chain family member 4.
    
 
 0.788
ENSCAFP00000063226
Uncharacterized protein; Belongs to the SKP1 family.
    
 0.783
SKP1
S-phase kinase associated protein 1; Belongs to the SKP1 family.
    
 
 0.654
ENSCAFP00000049197
Uncharacterized protein; Belongs to the SKP1 family.
    
 
 0.654
ENSCAFP00000051783
Uncharacterized protein; Belongs to the SKP1 family.
    
 
 0.654
RCBTB2
RCC1 and BTB domain containing protein 2.
      
 0.629
PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes (By similarity). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several order [...]
    
 
 0.626
FRMPD1
FERM and PDZ domain containing 1.
    
 
 0.601
CUL3
Cullin 3; Belongs to the cullin family.
   
 
 0.597
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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