STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TDRD7Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis (By similarity). (1098 aa)    
Predicted Functional Partners:
ALPK1
Alpha kinase 1.
   
    0.810
DDX25
DEAD-box helicase 25.
   
  
 0.770
NANOS1
Nanos-type domain-containing protein; Belongs to the nanos family.
   
  
 0.718
SYPL1
Synaptophysin like 1.
      
 0.675
TDRD9
Tudor domain containing 9.
   
 
 0.659
PIWIL2
Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family.
   
 
 0.642
GCNT2
Glucosaminyl (N-acetyl) transferase 2 (I blood group).
      
 0.574
CRYAA
Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
   
 
 0.574
NPTX2
Neuronal pentraxin 2.
    
 
 0.571
ZNF341
Zinc finger protein 341.
    
 
 0.562
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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