STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
XPAXPA, DNA damage recognition and repair factor. (273 aa)    
Predicted Functional Partners:
ERCC4
ERCC excision repair 4, endonuclease catalytic subunit.
    
 0.986
DDB2
Damage specific DNA binding protein 2.
   
 0.978
ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit.
   
 0.976
ERCC6
ERCC excision repair 6, chromatin remodeling factor.
   
 0.970
ERCC2
ERCC excision repair 2, TFIIH core complex helicase subunit.
    
 0.956
FANCM
FA complementation group M.
   
 
 0.954
ERCC3
ERCC excision repair 3, TFIIH core complex helicase subunit.
    
 0.940
GTF2H1
General transcription factor IIH subunit 1.
   
 0.940
ERCC5
Uncharacterized protein.
   
 0.901
RPA1
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
    
 0.885
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.