STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ANKS6Ankyrin repeat and sterile alpha motif domain containing 6. (856 aa)    
Predicted Functional Partners:
NEK8
NIMA related kinase 8.
    
 
 0.956
ANKS3
Ankyrin repeat and sterile alpha motif domain containing 3.
  
 
 
0.937
NPHP3
Nephrocystin 3.
    
 0.895
NEK6
NIMA related kinase 6; Belongs to the protein kinase superfamily.
    
 
 0.820
NEK7
NIMA related kinase 7; Belongs to the protein kinase superfamily.
    
 
 0.799
PLEKHG5
Pleckstrin homology and RhoGEF domain containing G5.
    
 0.783
TMEM100
Transmembrane protein 100.
      
 0.635
LANCL2
LanC like 2.
    
 0.626
NPHP1
Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly (By similarity). Required for n [...]
    
 0.620
CEP83
Centrosomal protein 83.
    
 0.616
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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