EYS protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

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Experiments

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[Homology]

Score

EYS

Uncharacterized protein. (2565 aa)

Predicted Functional Partners:

JAG1

0.886

NOTCH4

0.877

JAG2

0.875

RBPJ

0.874

NOTCH1

0.864

DLL1

0.859

NOTCH3

0.856

MAML1

0.854

MAML2

0.822

ABCA4

0.810

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA4	EYS	ENSCAFP00000004971	ENSCAFP00000003634	ATP binding cassette subfamily A member 4.	Uncharacterized protein.	0.810
DLL1	EYS	ENSCAFP00000006075	ENSCAFP00000003634	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.859
DLL1	MAML1	ENSCAFP00000006075	ENSCAFP00000000502	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 1.	0.745
DLL1	MAML2	ENSCAFP00000006075	ENSCAFP00000006055	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 2.	0.633
DLL1	NOTCH1	ENSCAFP00000006075	ENSCAFP00000029073	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.981
DLL1	NOTCH3	ENSCAFP00000006075	ENSCAFP00000023739	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.974
DLL1	NOTCH4	ENSCAFP00000006075	ENSCAFP00000001124	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 4.	0.976
DLL1	RBPJ	ENSCAFP00000006075	ENSCAFP00000064615	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.875
EYS	ABCA4	ENSCAFP00000003634	ENSCAFP00000004971	Uncharacterized protein.	ATP binding cassette subfamily A member 4.	0.810
EYS	DLL1	ENSCAFP00000003634	ENSCAFP00000006075	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.859
EYS	JAG1	ENSCAFP00000003634	ENSCAFP00000008417	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.886
EYS	JAG2	ENSCAFP00000003634	ENSCAFP00000027180	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.875
EYS	MAML1	ENSCAFP00000003634	ENSCAFP00000000502	Uncharacterized protein.	Mastermind like transcriptional coactivator 1.	0.854
EYS	MAML2	ENSCAFP00000003634	ENSCAFP00000006055	Uncharacterized protein.	Mastermind like transcriptional coactivator 2.	0.822
EYS	NOTCH1	ENSCAFP00000003634	ENSCAFP00000029073	Uncharacterized protein.	Notch receptor 1.	0.864
EYS	NOTCH3	ENSCAFP00000003634	ENSCAFP00000023739	Uncharacterized protein.	Notch receptor 3.	0.856
EYS	NOTCH4	ENSCAFP00000003634	ENSCAFP00000001124	Uncharacterized protein.	Notch receptor 4.	0.877
EYS	RBPJ	ENSCAFP00000003634	ENSCAFP00000064615	Uncharacterized protein.	Recombination signal binding protein for immunoglobulin kappa J region.	0.874
JAG1	EYS	ENSCAFP00000008417	ENSCAFP00000003634	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.886
JAG1	JAG2	ENSCAFP00000008417	ENSCAFP00000027180	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.950