STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NLRP5NLR family pyrin domain containing 5. (1142 aa)    
Predicted Functional Partners:
OOEP
Oocyte-expressed protein; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the KHDC1 family.
    
 0.961
F1Q3N3_CANLF
WD_REPEATS_REGION domain-containing protein.
    
 0.900
PADI6
Peptidyl arginine deiminase 6.
   
 
 0.899
ZP4
Zona pellucida glycoprotein 4.
   
 0.783
KHDC3L
KH domain containing 3 like, subcortical maternal complex member.
    
 
 0.766
ENSCAFP00000054102
MOEP19 domain-containing protein.
    
 
 0.729
PADI3
Peptidyl arginine deiminase 3.
   
 
 0.719
TSPAN32
Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family.
      
 0.688
ZP2
Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.
   
 0.684
GDF9
Growth differentiation factor 9.
   
 0.641
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.