| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DNMBP | MACC1 | ENSCAFP00000044264 | ENSCAFP00000003667 | Dynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation. Plays a key role in ciliogenesis and cyst formation. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). | MET transcriptional regulator MACC1. | 0.761 |
| DNMBP | MDC1 | ENSCAFP00000044264 | ENSCAFP00000000644 | Dynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation. Plays a key role in ciliogenesis and cyst formation. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). | Mediator of DNA damage checkpoint 1. | 0.527 |
| DNMBP | PAXIP1 | ENSCAFP00000044264 | ENSCAFP00000007562 | Dynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation. Plays a key role in ciliogenesis and cyst formation. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). | PAX interacting protein 1. | 0.527 |
| DNMBP | RRS1 | ENSCAFP00000044264 | ENSCAFP00000010848 | Dynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation. Plays a key role in ciliogenesis and cyst formation. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). | Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. | 0.698 |
| EPS15 | EPS15L1 | ENSCAFP00000005777 | ENSCAFP00000023135 | Epidermal growth factor receptor pathway substrate 15. | Epidermal growth factor receptor pathway substrate 15 like 1. | 0.981 |
| EPS15 | MACC1 | ENSCAFP00000005777 | ENSCAFP00000003667 | Epidermal growth factor receptor pathway substrate 15. | MET transcriptional regulator MACC1. | 0.471 |
| EPS15L1 | EPS15 | ENSCAFP00000023135 | ENSCAFP00000005777 | Epidermal growth factor receptor pathway substrate 15 like 1. | Epidermal growth factor receptor pathway substrate 15. | 0.981 |
| EPS15L1 | MACC1 | ENSCAFP00000023135 | ENSCAFP00000003667 | Epidermal growth factor receptor pathway substrate 15 like 1. | MET transcriptional regulator MACC1. | 0.421 |
| HGF | MACC1 | ENSCAFP00000009539 | ENSCAFP00000003667 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | MET transcriptional regulator MACC1. | 0.432 |
| HGF | MET | ENSCAFP00000009539 | ENSCAFP00000041478 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.998 |
| ITGA6 | ITGA7 | ENSCAFP00000054417 | ENSCAFP00000064043 | Integrin subunit alpha 6; Belongs to the integrin alpha chain family. | Integrin subunit alpha 7; Belongs to the integrin alpha chain family. | 0.549 |
| ITGA6 | MACC1 | ENSCAFP00000054417 | ENSCAFP00000003667 | Integrin subunit alpha 6; Belongs to the integrin alpha chain family. | MET transcriptional regulator MACC1. | 0.494 |
| ITGA7 | ITGA6 | ENSCAFP00000064043 | ENSCAFP00000054417 | Integrin subunit alpha 7; Belongs to the integrin alpha chain family. | Integrin subunit alpha 6; Belongs to the integrin alpha chain family. | 0.549 |
| ITGA7 | MACC1 | ENSCAFP00000064043 | ENSCAFP00000003667 | Integrin subunit alpha 7; Belongs to the integrin alpha chain family. | MET transcriptional regulator MACC1. | 0.430 |
| MACC1 | DNMBP | ENSCAFP00000003667 | ENSCAFP00000044264 | MET transcriptional regulator MACC1. | Dynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation. Plays a key role in ciliogenesis and cyst formation. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). | 0.761 |
| MACC1 | EPS15 | ENSCAFP00000003667 | ENSCAFP00000005777 | MET transcriptional regulator MACC1. | Epidermal growth factor receptor pathway substrate 15. | 0.471 |
| MACC1 | EPS15L1 | ENSCAFP00000003667 | ENSCAFP00000023135 | MET transcriptional regulator MACC1. | Epidermal growth factor receptor pathway substrate 15 like 1. | 0.421 |
| MACC1 | HGF | ENSCAFP00000003667 | ENSCAFP00000009539 | MET transcriptional regulator MACC1. | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.432 |
| MACC1 | ITGA6 | ENSCAFP00000003667 | ENSCAFP00000054417 | MET transcriptional regulator MACC1. | Integrin subunit alpha 6; Belongs to the integrin alpha chain family. | 0.494 |
| MACC1 | ITGA7 | ENSCAFP00000003667 | ENSCAFP00000064043 | MET transcriptional regulator MACC1. | Integrin subunit alpha 7; Belongs to the integrin alpha chain family. | 0.430 |