STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MACC1MET transcriptional regulator MACC1. (851 aa)    
Predicted Functional Partners:
PDE8B
Phosphodiesterase 8B; Belongs to the cyclic nucleotide phosphodiesterase family.
      
 0.515
PDE8A
Phosphodiesterase.
      
 0.515
SHKBP1
SH3KBP1 binding protein 1.
      
 0.506
KIAA1522
Uncharacterized protein.
      
 0.469
PACRGL
Parkin coregulated like.
   
  
 0.468
GUCD1
Uncharacterized protein.
      
 0.459
J9P4W2_CANLF
Uncharacterized protein.
      
 0.459
RRS1
Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.
      
 0.457
DNMBP
Dynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation. Plays a key role in ciliogenesis and cyst formation. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).
      
 0.457
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.