PPM1B protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PPM1B

Protein phosphatase, Mg2+/Mn2+ dependent 1B. (479 aa)

Predicted Functional Partners:

PPM1A

0.894

MAP3K7

0.852

PREPL

0.712

CHUK

0.699

SLC3A1

0.692

MAP2K4

0.664

GHRH

0.654

MAP2K7

0.641

USP38

0.566

MAP2K3

0.565

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	MAP3K7	ENSCAFP00000014093	ENSCAFP00000004664	Component of inhibitor of nuclear factor kappa B kinase complex.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.996
CHUK	PPM1A	ENSCAFP00000014093	ENSCAFP00000022940	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein phosphatase, Mg2+/Mn2+ dependent 1A.	0.525
CHUK	PPM1B	ENSCAFP00000014093	ENSCAFP00000003697	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein phosphatase, Mg2+/Mn2+ dependent 1B.	0.699
GHRH	PPM1B	ENSCAFP00000012862	ENSCAFP00000003697	Growth hormone releasing hormone.	Protein phosphatase, Mg2+/Mn2+ dependent 1B.	0.654
MAP2K3	MAP2K4	ENSCAFP00000061410	ENSCAFP00000049330	Mitogen-activated protein kinase kinase 3.	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.898
MAP2K3	MAP3K7	ENSCAFP00000061410	ENSCAFP00000004664	Mitogen-activated protein kinase kinase 3.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.974
MAP2K3	PPM1A	ENSCAFP00000061410	ENSCAFP00000022940	Mitogen-activated protein kinase kinase 3.	Protein phosphatase, Mg2+/Mn2+ dependent 1A.	0.893
MAP2K3	PPM1B	ENSCAFP00000061410	ENSCAFP00000003697	Mitogen-activated protein kinase kinase 3.	Protein phosphatase, Mg2+/Mn2+ dependent 1B.	0.565
MAP2K4	MAP2K3	ENSCAFP00000049330	ENSCAFP00000061410	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 3.	0.898
MAP2K4	MAP2K7	ENSCAFP00000049330	ENSCAFP00000040122	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 7.	0.963
MAP2K4	MAP3K7	ENSCAFP00000049330	ENSCAFP00000004664	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.991
MAP2K4	PPM1A	ENSCAFP00000049330	ENSCAFP00000022940	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Protein phosphatase, Mg2+/Mn2+ dependent 1A.	0.911
MAP2K4	PPM1B	ENSCAFP00000049330	ENSCAFP00000003697	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Protein phosphatase, Mg2+/Mn2+ dependent 1B.	0.664
MAP2K7	MAP2K4	ENSCAFP00000040122	ENSCAFP00000049330	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.963
MAP2K7	MAP3K7	ENSCAFP00000040122	ENSCAFP00000004664	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.987
MAP2K7	PPM1A	ENSCAFP00000040122	ENSCAFP00000022940	Mitogen-activated protein kinase kinase 7.	Protein phosphatase, Mg2+/Mn2+ dependent 1A.	0.894
MAP2K7	PPM1B	ENSCAFP00000040122	ENSCAFP00000003697	Mitogen-activated protein kinase kinase 7.	Protein phosphatase, Mg2+/Mn2+ dependent 1B.	0.641
MAP3K7	CHUK	ENSCAFP00000004664	ENSCAFP00000014093	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.996
MAP3K7	MAP2K3	ENSCAFP00000004664	ENSCAFP00000061410	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	Mitogen-activated protein kinase kinase 3.	0.974
MAP3K7	MAP2K4	ENSCAFP00000004664	ENSCAFP00000049330	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.991