STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SIX3SIX homeobox 3. (396 aa)    
Predicted Functional Partners:
VSX2
Visual system homeobox 2.
   
  
 0.733
LHX2
LIM homeobox 2.
   
 
 0.709
OTX2
Orthodenticle homeobox 2.
   
 
 0.668
EYA1
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
   
 
 0.653
TLE1
TLE family member 1, transcriptional corepressor.
    
 
 0.623
NR4A3
Nuclear receptor subfamily 4 group A member 3.
    
 
 0.617
SHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
    
 
 0.534
RNF32
Ring finger protein 32.
      
 0.533
DLX2
Distal-less homeobox 2.
      
 0.521
GBX2
Gastrulation brain homeobox 2.
    
 
 0.519
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.