SIX2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

SIX2

SIX homeobox 2. (298 aa)

Predicted Functional Partners:

EYA1

0.868

EYA2

0.841

CITED1

0.796

PAX2

0.744

EYA4

0.687

WT1

0.687

EYA3

0.679

LHX1

0.670

WNT9B

0.580

PAX8

0.533

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CITED1	EYA1	ENSCAFP00000025268	ENSCAFP00000048581	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.692
CITED1	EYA4	ENSCAFP00000025268	ENSCAFP00000041774	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.470
CITED1	LHX1	ENSCAFP00000025268	ENSCAFP00000026343	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	LIM homeobox 1.	0.760
CITED1	PAX2	ENSCAFP00000025268	ENSCAFP00000057653	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	Paired box 2.	0.400
CITED1	PAX8	ENSCAFP00000025268	ENSCAFP00000010846	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.	0.529
CITED1	SIX2	ENSCAFP00000025268	ENSCAFP00000003716	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	SIX homeobox 2.	0.796
CITED1	WNT9B	ENSCAFP00000025268	ENSCAFP00000039322	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.685
CITED1	WT1	ENSCAFP00000025268	ENSCAFP00000058748	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	WT1 transcription factor.	0.630
EYA1	CITED1	ENSCAFP00000048581	ENSCAFP00000025268	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	0.692
EYA1	PAX2	ENSCAFP00000048581	ENSCAFP00000057653	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Paired box 2.	0.705
EYA1	PAX8	ENSCAFP00000048581	ENSCAFP00000010846	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.	0.779
EYA1	SIX2	ENSCAFP00000048581	ENSCAFP00000003716	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 2.	0.868
EYA1	WNT9B	ENSCAFP00000048581	ENSCAFP00000039322	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.419
EYA2	SIX2	ENSCAFP00000064084	ENSCAFP00000003716	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 2.	0.841
EYA3	SIX2	ENSCAFP00000017584	ENSCAFP00000003716	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 2.	0.679
EYA4	CITED1	ENSCAFP00000041774	ENSCAFP00000025268	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	0.470
EYA4	PAX8	ENSCAFP00000041774	ENSCAFP00000010846	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.	0.529
EYA4	SIX2	ENSCAFP00000041774	ENSCAFP00000003716	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 2.	0.687
LHX1	CITED1	ENSCAFP00000026343	ENSCAFP00000025268	LIM homeobox 1.	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	0.760
LHX1	PAX2	ENSCAFP00000026343	ENSCAFP00000057653	LIM homeobox 1.	Paired box 2.	0.716