STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EPAS1Endothelial PAS domain protein 1. (868 aa)    
Predicted Functional Partners:
EGLN1
Egl-9 family hypoxia inducible factor 1.
   
 0.991
VHL
Von Hippel-Lindau disease tumor suppressor; Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (By similarity).
    
 0.990
EP300
E1A binding protein p300.
    
 0.984
ARNT
Aryl hydrocarbon receptor nuclear translocator.
   
0.983
ARNT2
Aryl hydrocarbon receptor nuclear translocator 2.
   
 0.980
EGLN3
Egl-9 family hypoxia inducible factor 3.
    
 0.977
EGLN2
Egl-9 family hypoxia inducible factor 2.
    
 0.972
ELOB
Elongin B.
    
 0.969
CREBBP
CREB binding protein.
   
 0.964
CUL2
Cullin 2; Belongs to the cullin family.
    
 0.962
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.