EPCAM protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EPCAM

Epithelial cell adhesion molecule. (293 aa)

Predicted Functional Partners:

CLDN7

0.773

CD44

0.719

ENSCAFP00000062374

0.700

MSH2

0.681

CDH1

0.668

MSH6

0.642

PMS2

0.636

MUC1

0.630

EGFR

0.629

E2R960_CANLF

0.629

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD44	CDH1	ENSCAFP00000050335	ENSCAFP00000030112	CD44 antigen.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	0.656
CD44	E2R960_CANLF	ENSCAFP00000050335	ENSCAFP00000010742	CD44 antigen.	Uncharacterized protein.	0.797
CD44	EGFR	ENSCAFP00000050335	ENSCAFP00000005164	CD44 antigen.	Receptor protein-tyrosine kinase.	0.974
CD44	EPCAM	ENSCAFP00000050335	ENSCAFP00000003865	CD44 antigen.	Epithelial cell adhesion molecule.	0.719
CD44	MUC1	ENSCAFP00000050335	ENSCAFP00000025082	CD44 antigen.	Mucin 1, cell surface associated.	0.505
CDH1	CD44	ENSCAFP00000030112	ENSCAFP00000050335	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	CD44 antigen.	0.656
CDH1	CLDN7	ENSCAFP00000030112	ENSCAFP00000023751	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.509
CDH1	EGFR	ENSCAFP00000030112	ENSCAFP00000005164	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	Receptor protein-tyrosine kinase.	0.870
CDH1	ENSCAFP00000062374	ENSCAFP00000030112	ENSCAFP00000062374	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.495
CDH1	EPCAM	ENSCAFP00000030112	ENSCAFP00000003865	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	Epithelial cell adhesion molecule.	0.668
CDH1	MUC1	ENSCAFP00000030112	ENSCAFP00000025082	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	Mucin 1, cell surface associated.	0.524
CLDN7	CDH1	ENSCAFP00000023751	ENSCAFP00000030112	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	0.509
CLDN7	EPCAM	ENSCAFP00000023751	ENSCAFP00000003865	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Epithelial cell adhesion molecule.	0.773
E2R960_CANLF	CD44	ENSCAFP00000010742	ENSCAFP00000050335	Uncharacterized protein.	CD44 antigen.	0.797
E2R960_CANLF	ENSCAFP00000062374	ENSCAFP00000010742	ENSCAFP00000062374	Uncharacterized protein.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.608
E2R960_CANLF	EPCAM	ENSCAFP00000010742	ENSCAFP00000003865	Uncharacterized protein.	Epithelial cell adhesion molecule.	0.629
EGFR	CD44	ENSCAFP00000005164	ENSCAFP00000050335	Receptor protein-tyrosine kinase.	CD44 antigen.	0.974
EGFR	CDH1	ENSCAFP00000005164	ENSCAFP00000030112	Receptor protein-tyrosine kinase.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	0.870
EGFR	ENSCAFP00000062374	ENSCAFP00000005164	ENSCAFP00000062374	Receptor protein-tyrosine kinase.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.437
EGFR	EPCAM	ENSCAFP00000005164	ENSCAFP00000003865	Receptor protein-tyrosine kinase.	Epithelial cell adhesion molecule.	0.629