node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD4 | CD44 | ENSCAFP00000063394 | ENSCAFP00000050335 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | CD44 antigen. | 0.865 |
CD4 | CDH1 | ENSCAFP00000063394 | ENSCAFP00000030112 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | 0.487 |
CD4 | E2R960_CANLF | ENSCAFP00000063394 | ENSCAFP00000010742 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Uncharacterized protein. | 0.487 |
CD4 | EGFR | ENSCAFP00000063394 | ENSCAFP00000005164 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Receptor protein-tyrosine kinase. | 0.569 |
CD4 | EPCAM | ENSCAFP00000063394 | ENSCAFP00000003865 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Epithelial cell adhesion molecule. | 0.613 |
CD4 | ITGB1 | ENSCAFP00000063394 | ENSCAFP00000005722 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Integrin beta; Belongs to the integrin beta chain family. | 0.522 |
CD4 | MUC1 | ENSCAFP00000063394 | ENSCAFP00000025082 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Mucin 1, cell surface associated. | 0.504 |
CD44 | CD4 | ENSCAFP00000050335 | ENSCAFP00000063394 | CD44 antigen. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.865 |
CD44 | CDH1 | ENSCAFP00000050335 | ENSCAFP00000030112 | CD44 antigen. | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | 0.778 |
CD44 | CLDN7 | ENSCAFP00000050335 | ENSCAFP00000023751 | CD44 antigen. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.475 |
CD44 | E2R960_CANLF | ENSCAFP00000050335 | ENSCAFP00000010742 | CD44 antigen. | Uncharacterized protein. | 0.746 |
CD44 | EGFR | ENSCAFP00000050335 | ENSCAFP00000005164 | CD44 antigen. | Receptor protein-tyrosine kinase. | 0.924 |
CD44 | ENSCAFP00000062374 | ENSCAFP00000050335 | ENSCAFP00000062374 | CD44 antigen. | IF rod domain-containing protein; Belongs to the intermediate filament family. | 0.489 |
CD44 | EPCAM | ENSCAFP00000050335 | ENSCAFP00000003865 | CD44 antigen. | Epithelial cell adhesion molecule. | 0.776 |
CD44 | ITGB1 | ENSCAFP00000050335 | ENSCAFP00000005722 | CD44 antigen. | Integrin beta; Belongs to the integrin beta chain family. | 0.810 |
CD44 | LGR5 | ENSCAFP00000050335 | ENSCAFP00000066431 | CD44 antigen. | Leucine rich repeat containing G protein-coupled receptor 5. | 0.641 |
CD44 | MUC1 | ENSCAFP00000050335 | ENSCAFP00000025082 | CD44 antigen. | Mucin 1, cell surface associated. | 0.540 |
CDH1 | CD4 | ENSCAFP00000030112 | ENSCAFP00000063394 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.487 |
CDH1 | CD44 | ENSCAFP00000030112 | ENSCAFP00000050335 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | CD44 antigen. | 0.778 |
CDH1 | CLDN7 | ENSCAFP00000030112 | ENSCAFP00000023751 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.626 |