STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TTYH1Protein tweety homolog; Probable chloride channel. (460 aa)    
Predicted Functional Partners:
CDC42EP5
CDC42 effector protein 5.
      
 0.791
LENG8
Leukocyte receptor cluster member 8.
      
 0.788
LRRC8C
Leucine rich repeat containing 8 VRAC subunit C.
      
 0.717
EVC2
EvC ciliary complex subunit 2.
     
 0.593
EVC
EvC ciliary complex subunit 1.
     
  0.593
EFCAB7
EF-hand calcium binding domain 7.
     
  0.593
GP6
Glycoprotein VI platelet.
   
  
 0.575
LRRC8A
Leucine rich repeat containing 8 VRAC subunit A.
      
 0.555
LRRC8E
Leucine rich repeat containing 8 VRAC subunit E.
      
 0.533
UNK
RING finger protein unkempt homolog; Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes. Belongs to the unkempt family.
      
 0.495
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.