STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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[Homology]
Score
E2R7S0_CANLFCleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (231 aa)    
Predicted Functional Partners:
CPSF6
Cleavage and polyadenylation specific factor 6.
   
 
 0.908
CPSF7
Cleavage and polyadenylation specific factor 7.
   
 
 0.855
PCF11
PCF11 cleavage and polyadenylation factor subunit.
    
 
 0.786
FIP1L1
Factor interacting with PAPOLA and CPSF1.
   
 
 0.656
SFPQ
Splicing factor proline and glutamine rich.
   
 
 0.603
ZC3H6
Zinc finger CCCH-type containing 6.
    
 
 0.597
YTHDC2
YTH domain containing 2.
   
 
 0.592
YTHDC1
YTH domain containing 1.
   
 
 0.585
CPSF4
Cleavage and polyadenylation specific factor 4.
    
 
 0.578
MYL6
Uncharacterized protein.
   
   0.572
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.