GPNMB protein (Canis lupus familiaris) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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[Homology]

Score

GPNMB

Glycoprotein nmb. (554 aa)

Predicted Functional Partners:

CLEC1A

0.772

TREM2

0.769

CTSB

0.686

APOE

0.623

TFEC

0.604

LGALS3

0.594

ENSCAFP00000062504

0.594

TPPP

0.589

J9P9J2_CANLF

0.588

C1QA

0.587

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOE	C1QA	ENSCAFP00000006888	ENSCAFP00000040393	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Complement C1q A chain.	0.733
APOE	CLEC1A	ENSCAFP00000006888	ENSCAFP00000045947	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	C-type lectin domain containing 7A.	0.694
APOE	CTSB	ENSCAFP00000006888	ENSCAFP00000059573	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Cathepsin B; Belongs to the peptidase C1 family.	0.682
APOE	ENSCAFP00000062504	ENSCAFP00000006888	ENSCAFP00000062504	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Galectin.	0.458
APOE	GPNMB	ENSCAFP00000006888	ENSCAFP00000004059	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Glycoprotein nmb.	0.623
APOE	LGALS3	ENSCAFP00000006888	ENSCAFP00000022105	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Galectin-3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage [...]	0.570
APOE	TREM2	ENSCAFP00000006888	ENSCAFP00000051676	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Triggering receptor expressed on myeloid cells 2.	0.946
C1QA	APOE	ENSCAFP00000040393	ENSCAFP00000006888	Complement C1q A chain.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.733
C1QA	CLEC1A	ENSCAFP00000040393	ENSCAFP00000045947	Complement C1q A chain.	C-type lectin domain containing 7A.	0.623
C1QA	CTSB	ENSCAFP00000040393	ENSCAFP00000059573	Complement C1q A chain.	Cathepsin B; Belongs to the peptidase C1 family.	0.555
C1QA	GPNMB	ENSCAFP00000040393	ENSCAFP00000004059	Complement C1q A chain.	Glycoprotein nmb.	0.587
C1QA	TREM2	ENSCAFP00000040393	ENSCAFP00000051676	Complement C1q A chain.	Triggering receptor expressed on myeloid cells 2.	0.898
CLEC1A	APOE	ENSCAFP00000045947	ENSCAFP00000006888	C-type lectin domain containing 7A.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.694
CLEC1A	C1QA	ENSCAFP00000045947	ENSCAFP00000040393	C-type lectin domain containing 7A.	Complement C1q A chain.	0.623
CLEC1A	CTSB	ENSCAFP00000045947	ENSCAFP00000059573	C-type lectin domain containing 7A.	Cathepsin B; Belongs to the peptidase C1 family.	0.408
CLEC1A	ENSCAFP00000062504	ENSCAFP00000045947	ENSCAFP00000062504	C-type lectin domain containing 7A.	Galectin.	0.526
CLEC1A	GPNMB	ENSCAFP00000045947	ENSCAFP00000004059	C-type lectin domain containing 7A.	Glycoprotein nmb.	0.772
CLEC1A	LGALS3	ENSCAFP00000045947	ENSCAFP00000022105	C-type lectin domain containing 7A.	Galectin-3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage [...]	0.602
CLEC1A	TREM2	ENSCAFP00000045947	ENSCAFP00000051676	C-type lectin domain containing 7A.	Triggering receptor expressed on myeloid cells 2.	0.821
CTSB	APOE	ENSCAFP00000059573	ENSCAFP00000006888	Cathepsin B; Belongs to the peptidase C1 family.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.682