STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MEI4Meiotic double-stranded break formation protein 4. (386 aa)    
Predicted Functional Partners:
REC114
REC114 meiotic recombination protein.
    
 
 0.862
CENPQ
Centromere protein Q.
      
 0.804
CENPV
Centromere protein V.
      
 0.611
KIAA0319
KIAA0319.
      
 0.609
PNKP
Polynucleotide kinase 3'-phosphatase.
    
 
 0.577
CCDC36
Coiled-coil domain containing 36.
      
 0.473
RNF212
Ring finger protein 212.
      
 0.472
RAE1
SPO11 initiator of meiotic double stranded breaks.
      
 0.468
MLH3
MutL homolog 3.
      
 0.400
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.