STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMPRSS11ATransmembrane protease serine; Belongs to the peptidase S1 family. (424 aa)    
Predicted Functional Partners:
TMPRSS2
Uncharacterized protein.
      
 0.677
SLC13A2
Solute carrier family 13 member 2.
   
  
 0.641
FURIN
Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.
   
  
 0.604
IGSF9B
Immunoglobulin superfamily member 9B.
   
 
 0.586
CTSL3
Uncharacterized protein; Belongs to the peptidase C1 family.
 
 
  
 0.583
LOC102156614
Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.
 
    
 0.573
PDCL2
Phosducin like 2.
   
  
 0.573
SLC46A2
Thymic stromal cotransporter homolog; May act as a transporter (By similarity). May be involved in establishing and maintaining the luminal fluid microenvironment.
   
  
 0.573
LRRN4CL
LRRN4 C-terminal like.
      
 0.572
SERPINB7
Serpin family B member 7; Belongs to the serpin family.
   
 
 0.565
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.