STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (711 aa)    
Predicted Functional Partners:
KCNQ1
Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family.
  
0.940
KCNQ5
Potassium voltage-gated channel subfamily Q member 5.
  
  
0.938
KCNJ2
Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Blocked b [...]
   
 
 0.929
KCNJ12
Inward rectifier potassium channel.
   
 
 0.926
KCNQ3
Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family.
    
 0.904
KCNJ14
Potassium voltage-gated channel subfamily J member 14.
   
 
 0.898
KCNJ4
Potassium voltage-gated channel subfamily J member 4.
   
 
 0.896
KCNQ2
Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family.
     
  0.881
KCNE1
Uncharacterized protein.
    
 0.808
KCNE3
Potassium voltage-gated channel subfamily E regulatory subunit 3.
   
 0.803
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.