STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLK14Kallikrein related-peptidase 14; Belongs to the peptidase S1 family. (251 aa)    
Predicted Functional Partners:
SPINK6
Serine peptidase inhibitor, Kazal type 6.
    
 0.910
SPINK5
Serine peptidase inhibitor, Kazal type 5.
   
 
 0.698
CDSN
Corneodesmosin.
   
 
 0.615
APP
Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]
    
 
 0.580
KRT80
Keratin 80; Belongs to the intermediate filament family.
   
  
 0.567
IGSF9B
Immunoglobulin superfamily member 9B.
    
 
 0.551
TGM3
Transglutaminase 3.
      
 0.547
TGM5
Transglutaminase 5.
   
  
 0.540
TFPI
Tissue factor pathway inhibitor.
    
 
 0.530
KRT84
Keratin 84; Belongs to the intermediate filament family.
   
 
 0.520
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.