STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CSN3Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family. (185 aa)    
Predicted Functional Partners:
CSN2
Beta-casein; Important role in determination of the surface properties of the casein micelles.
   
  
 0.981
CSN1S1
Casein alpha s1.
   
 
 0.953
LALBA
Alpha-lactalbumin; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N- acetylglucosamine of the oligosaccharide chains in glycoproteins; Belongs to the glycosyl hydrolase 22 family.
   
  
 0.947
LOC100856000
Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.
   
  
 0.906
LTF
Uncharacterized protein; Belongs to the transferrin family.
   
  
 0.700
LOC491263
Beta-lactoglobulin-2; Primary component of whey, it binds retinol and is probably involved in the transport of that molecule; Belongs to the calycin superfamily. Lipocalin family.
   
 
 0.671
SCD
Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family.
      
 0.639
LYZ
Lysozyme C, spleen isozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents; Belongs to the glycosyl hydrolase 22 family.
   
  
 0.623
PIGR
Uncharacterized protein.
   
  
 0.613
SLC11A1
Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...]
   
  
 0.589
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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