GCK protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GCK

Phosphotransferase. (226 aa)

Predicted Functional Partners:

GCKR

0.983

G6PC

0.983

G6PC2

0.980

GPI

0.966

ADPGK

0.951

HK3

0.945

HKDC1

0.945

HK2

0.944

HK1

0.944

PGM1

0.938

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADPGK	G6PC	ENSCAFP00000026156	ENSCAFP00000021606	ADP dependent glucokinase.	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	0.900
ADPGK	G6PC2	ENSCAFP00000026156	ENSCAFP00000017476	ADP dependent glucokinase.	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.900
ADPGK	GCK	ENSCAFP00000026156	ENSCAFP00000004364	ADP dependent glucokinase.	Phosphotransferase.	0.951
ADPGK	GPI	ENSCAFP00000026156	ENSCAFP00000010874	ADP dependent glucokinase.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.985
ADPGK	HK1	ENSCAFP00000026156	ENSCAFP00000020540	ADP dependent glucokinase.	Hexokinase 1.	0.942
ADPGK	HK2	ENSCAFP00000026156	ENSCAFP00000012208	ADP dependent glucokinase.	Hexokinase 2.	0.934
ADPGK	HK3	ENSCAFP00000026156	ENSCAFP00000024410	ADP dependent glucokinase.	Hexokinase 3.	0.944
ADPGK	HKDC1	ENSCAFP00000026156	ENSCAFP00000035961	ADP dependent glucokinase.	Hexokinase domain containing 1.	0.943
ADPGK	PGM1	ENSCAFP00000026156	ENSCAFP00000057497	ADP dependent glucokinase.	Phosphoglucomutase 1; Belongs to the phosphohexose mutase family.	0.907
G6PC	ADPGK	ENSCAFP00000021606	ENSCAFP00000026156	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	ADP dependent glucokinase.	0.900
G6PC	G6PC2	ENSCAFP00000021606	ENSCAFP00000017476	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.904
G6PC	GCK	ENSCAFP00000021606	ENSCAFP00000004364	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Phosphotransferase.	0.983
G6PC	GPI	ENSCAFP00000021606	ENSCAFP00000010874	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.925
G6PC	HK1	ENSCAFP00000021606	ENSCAFP00000020540	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Hexokinase 1.	0.959
G6PC	HK2	ENSCAFP00000021606	ENSCAFP00000012208	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Hexokinase 2.	0.956
G6PC	HK3	ENSCAFP00000021606	ENSCAFP00000024410	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Hexokinase 3.	0.959
G6PC	HKDC1	ENSCAFP00000021606	ENSCAFP00000035961	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Hexokinase domain containing 1.	0.959
G6PC	PGM1	ENSCAFP00000021606	ENSCAFP00000057497	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Phosphoglucomutase 1; Belongs to the phosphohexose mutase family.	0.946
G6PC2	ADPGK	ENSCAFP00000017476	ENSCAFP00000026156	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	ADP dependent glucokinase.	0.900
G6PC2	G6PC	ENSCAFP00000017476	ENSCAFP00000021606	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	0.904