HOXA4 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

HOXA4

Homeobox A4. (317 aa)

Predicted Functional Partners:

HOXD4

0.931

HOXA3

0.677

DGKK

0.591

HOXA2

0.536

EIF2D

0.527

DNAL4

0.440

BNC2

0.435

SRD5A2

0.425

PGAM2

0.423

PAX8

0.419

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNC2	DGKK	ENSCAFP00000057543	ENSCAFP00000047501	Basonuclin 2.	Diacylglycerol kinase.	0.543
BNC2	HOXA4	ENSCAFP00000057543	ENSCAFP00000004370	Basonuclin 2.	Homeobox A4.	0.435
BNC2	SRD5A2	ENSCAFP00000057543	ENSCAFP00000037968	Basonuclin 2.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.434
DGKK	BNC2	ENSCAFP00000047501	ENSCAFP00000057543	Diacylglycerol kinase.	Basonuclin 2.	0.543
DGKK	HOXA4	ENSCAFP00000047501	ENSCAFP00000004370	Diacylglycerol kinase.	Homeobox A4.	0.591
DGKK	SRD5A2	ENSCAFP00000047501	ENSCAFP00000037968	Diacylglycerol kinase.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.647
DNAL4	HOXA4	ENSCAFP00000001956	ENSCAFP00000004370	Dynein light chain.	Homeobox A4.	0.440
EIF2D	HOXA4	ENSCAFP00000034745	ENSCAFP00000004370	Eukaryotic translation initiation factor 2D.	Homeobox A4.	0.527
HOXA2	HOXA3	ENSCAFP00000004363	ENSCAFP00000037493	Homeobox A2.	Homeobox A3.	0.721
HOXA2	HOXA4	ENSCAFP00000004363	ENSCAFP00000004370	Homeobox A2.	Homeobox A4.	0.536
HOXA2	PAX8	ENSCAFP00000004363	ENSCAFP00000010846	Homeobox A2.	Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.	0.531
HOXA3	HOXA2	ENSCAFP00000037493	ENSCAFP00000004363	Homeobox A3.	Homeobox A2.	0.721
HOXA3	HOXA4	ENSCAFP00000037493	ENSCAFP00000004370	Homeobox A3.	Homeobox A4.	0.677
HOXA3	HOXD4	ENSCAFP00000037493	ENSCAFP00000019812	Homeobox A3.	Homeobox D4.	0.477
HOXA4	BNC2	ENSCAFP00000004370	ENSCAFP00000057543	Homeobox A4.	Basonuclin 2.	0.435
HOXA4	DGKK	ENSCAFP00000004370	ENSCAFP00000047501	Homeobox A4.	Diacylglycerol kinase.	0.591
HOXA4	DNAL4	ENSCAFP00000004370	ENSCAFP00000001956	Homeobox A4.	Dynein light chain.	0.440
HOXA4	EIF2D	ENSCAFP00000004370	ENSCAFP00000034745	Homeobox A4.	Eukaryotic translation initiation factor 2D.	0.527
HOXA4	HOXA2	ENSCAFP00000004370	ENSCAFP00000004363	Homeobox A4.	Homeobox A2.	0.536
HOXA4	HOXA3	ENSCAFP00000004370	ENSCAFP00000037493	Homeobox A4.	Homeobox A3.	0.677